A Caltech Library Service

Impact of air pollution on intestinal redox lipidome and microbiome

Feng, Juan and Cavallero, Susana and Hsiai, Tzung and Li, Rongsong (2020) Impact of air pollution on intestinal redox lipidome and microbiome. Free Radical Biology and Medicine, 151 . pp. 99-110. ISSN 0891-5849.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Air pollution is a rising public health issue worldwide. Cumulative epidemiological and experimental studies have shown that exposure to air pollution such as particulate matter (PM) is linked with increased hospital admissions and all-cause mortality. While previous studies on air pollution mostly focused on the respiratory and cardiovascular effects, emerging evidence supports a significant impact of air pollution on the gastrointestinal (GI) system. The gut is exposed to PM as most of the inhaled particles are removed from the lungs to the GI tract via mucociliary clearance. Ingestion of contaminated food and water is another common source of GI tract exposure to pollutants. Recent studies have associated air pollution with intestinal diseases, including appendicitis, colorectal cancer, and inflammatory bowel disease. In addition to the liver and adipose tissue, intestine is an important organ system for lipid metabolism, and the intestinal redox lipids might be tightly associated with the intestinal and systematic inflammation. The gut microbiota modulates lipid metabolism and contributes to the initiation and development of intestinal disease including inflammatory bowel disease. Recent data support microbiome implication in air pollution-mediated intestinal and systematic effects. In this review, the associations between air pollution and intestinal diseases, and the alterations of intestinal lipidome and gut microbiome by air pollution are highlighted. The potential mechanistic aspects underlying air pollution-mediated intestinal pathology will also be discussed.

Item Type:Article
Related URLs:
URLURL TypeDescription
Hsiai, Tzung0000-0003-1734-0792
Additional Information:© 2020 Elsevier Inc. Received 13 November 2019, Revised 29 December 2019, Accepted 30 December 2019, Available online 2 January 2020.
Funding AgencyGrant Number
Shenzhen Technology UniversityR01ES029395
Subject Keywords:Air pollution; Intestinal redox lipidome; Intestinal microbiome
Record Number:CaltechAUTHORS:20200103-111758763
Persistent URL:
Official Citation:Juan Feng, Susana Cavallero, Tzung Hsiai, Rongsong Li, Impact of air pollution on intestinal redox lipidome and microbiome, Free Radical Biology and Medicine, Volume 151, 2020, Pages 99-110, ISSN 0891-5849, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:100502
Deposited By: Tony Diaz
Deposited On:05 Jan 2020 00:05
Last Modified:08 Jun 2020 20:53

Repository Staff Only: item control page