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Neural Control and Modulation of Thirst, Sodium Appetite, and Hunger

Augustine, Vineet and Lee, Sangjun and Oka, Yuki (2020) Neural Control and Modulation of Thirst, Sodium Appetite, and Hunger. Cell, 180 (1). pp. 25-32. ISSN 0092-8674. PMCID PMC7406138. https://resolver.caltech.edu/CaltechAUTHORS:20200110-142757851

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Abstract

The function of central appetite neurons is instructing animals to ingest specific nutrient factors that the body needs. Emerging evidence suggests that individual appetite circuits for major nutrients—water, sodium, and food—operate on unique driving and quenching mechanisms. This review focuses on two aspects of appetite regulation. First, we describe the temporal relationship between appetite neuron activity and consumption behaviors. Second, we summarize ingestion-related satiation signals that differentially quench individual appetite circuits. We further discuss how distinct appetite and satiation systems for each factor may contribute to nutrient homeostasis from the functional and evolutional perspectives.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.cell.2019.11.040DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406138PubMed CentralArticle
ORCID:
AuthorORCID
Augustine, Vineet0000-0003-4431-1663
Lee, Sangjun0000-0002-0846-8252
Oka, Yuki0000-0003-2686-0677
Additional Information:© 2019 Elsevier Inc. Available online 9 January 2020. We thank the Oka lab members and D.J. Anderson for helpful discussion. This work was supported by startup funds from the California Institute of Technology. Y.O. is also supported by the Searle Scholars Program, the Mallinckrodt Foundation, the McKnight Foundation and the Klingenstein-Simons Foundation, and the NIH (U01 NS099717, R56MH113030, R01NS109997).
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funders:
Funding AgencyGrant Number
CaltechUNSPECIFIED
Searle Scholars ProgramUNSPECIFIED
Edward Mallinckrodt, Jr. FoundationUNSPECIFIED
McKnight FoundationUNSPECIFIED
Klingenstein-Simons FoundationUNSPECIFIED
NIHU01 NS099717
NIHR56MH113030
NIHR01NS109997
Issue or Number:1
PubMed Central ID:PMC7406138
Record Number:CaltechAUTHORS:20200110-142757851
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200110-142757851
Official Citation:Vineet Augustine, Sangjun Lee, Yuki Oka, Neural Control and Modulation of Thirst, Sodium Appetite, and Hunger, Cell, Volume 180, Issue 1, 2020, Pages 25-32, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2019.11.040. (http://www.sciencedirect.com/science/article/pii/S009286741931325X)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:100636
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Jan 2020 00:33
Last Modified:04 Nov 2020 20:59

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