CaltechAUTHORS
  A Caltech Library Service

Increased plasma CD14 levels 1 year postpartum in women with pre-eclampsia during pregnancy: a case–control plasma proteomics study

Manousopoulou, Antigoni and Abad, Fatma S. and Garay-Baquero, Diana J. and Birch, Brian R. and van Rijn, Bas B. and Lwaleed, Bashir A. and Garbis, Spiros D. (2020) Increased plasma CD14 levels 1 year postpartum in women with pre-eclampsia during pregnancy: a case–control plasma proteomics study. Nutrition and Diabetes, 10 . Art. No. 2. ISSN 2044-4052. PMCID PMC7026086. https://resolver.caltech.edu/CaltechAUTHORS:20200114-110651982

[img] PDF - Published Version
Creative Commons Attribution.

791Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20200114-110651982

Abstract

Epidemiological data suggest that pre-eclampsia (PE) is associated with an increased risk of post-delivery metabolic dysregulation. The aim of the present case–control observational study was to examine the global plasma proteomic profile 1 year postpartum in women who developed PE during pregnancy (n = 5) compared to controls (n = 5), in order to identify a novel predictive marker linking PE with long-term metabolic imbalance. Key findings were verified with enzyme-linked immunosorbent assay (ELISA) in a separate cohort (n = 17 women with PE and n = 43 controls). One hundred and seventy-two proteins were differentially expressed in the PE vs. control groups. Gene ontology analysis showed that Inflammatory|Immune responses, Blood coagulation and Metabolism were significantly enriched terms. CD14, mapping to the inflammatory response protein network, was selected for verification based on bibliographic evidence. ELISA measurements showed CD14 to be significantly increased 1 year postpartum in women with PE during pregnancy compared to controls [PE group (median ± SD): 296.5 ± 113.6; control group (median ± SD): 128.9 ± 98.5; Mann–Whitney U test p = 0.0078]. Overall, the identified proteins could provide insight into the long-term disease risk among women with PE during pregnancy and highlight the need for their postpartum monitoring. CD14 could be examined in larger cohorts as a predictive marker of insulin resistance and type II diabetes mellitus among women with PE.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1038/s41387-019-0105-xDOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7026086/PubMed CentralArticle
ORCID:
AuthorORCID
Manousopoulou, Antigoni0000-0001-5028-1865
Garay-Baquero, Diana J.0000-0002-9450-8504
Garbis, Spiros D.0000-0002-1050-0805
Additional Information:© 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Received 01 October 2019; Revised 09 December 2019; Accepted 18 December 2019; Published 14 January 2020. The study was support by the Ministry of the Higher Education and Scientific Research, Libya. Author Contributions: These authors contributed equally: Antigoni Manousopoulou, Fatma S. Abad. These authors jointly supervised this work: Bashir A. Lwaleed, Spiros D. Garbis. The authors declare that they have no conflict of interest.
Funders:
Funding AgencyGrant Number
Ministry of the Higher Education and Scientific Research (Libya)UNSPECIFIED
Subject Keywords:Endocrine system and metabolic diseases; Risk factors
PubMed Central ID:PMC7026086
Record Number:CaltechAUTHORS:20200114-110651982
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200114-110651982
Official Citation:Manousopoulou, A., Abad, F.S., Garay-Baquero, D.J. et al. Increased plasma CD14 levels 1 year postpartum in women with pre-eclampsia during pregnancy: a case–control plasma proteomics study. Nutr. Diabetes 10, 2 (2020) doi:10.1038/s41387-019-0105-x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:100717
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 Jan 2020 21:12
Last Modified:02 Apr 2020 21:10

Repository Staff Only: item control page