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Xanthogranuloma of the choroid plexus in the fat‐tailed dwarf lemur (Cheirogaleus medius)

Lee, Jason T. and Miller, Carol A. and McDonald, Colin T. and Allman, John M. (1996) Xanthogranuloma of the choroid plexus in the fat‐tailed dwarf lemur (Cheirogaleus medius). American Journal of Primatology, 38 (4). pp. 349-355. ISSN 0275-2565. https://resolver.caltech.edu/CaltechAUTHORS:20200114-151646549

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Abstract

This report documents the death of two fat‐tailed dwarf lemurs (Cheirogaleus medius) maintained over 6 years each in our laboratory. Postmortem studies revealed xanthogranuloma of the choroid plexus, a mass replete with stored lipids, including cholesterol crystals. Six months prior to their deaths, both animals developed a peculiar head tilt and signs suggestive of neurological dysfunction. At autopsy, each had masses projecting into the lateral and IVth ventricles and an associated obstructive hydrocephalus. Cryostat sections of the brains of both lemurs showed histological features consistent with xanthogranuloma of the choroid plexus, a histologically benign and usually asymptomatic lesion found in up to 7% of human autopsies. This case is of special interest because of the unique feeding strategies in the fat‐tailed dwarf lemur. Since C. medius remains in torpor for 6 months out of the year during the time of food scarcity in the forests of Madagascar, the animal must accumulate large reserves of fat during its active period. In the laboratory, however, dwarf lemurs do not normally go into torpor, and the accumulated fat is not used. The finding of this tumor, therefore, suggests that the combination of a captive high‐fat diet and the unusual fat‐storage mechanisms utilized by C. medius contributed to the buildup of lipids and might be etiologically related to the development of those lesions.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/(SICI)1098-2345(1996)38:4%3C349::AID-AJP5%3E3.0.CO;2-ZDOIArticle
Additional Information:© 1996 Wiley-Liss, Inc. Received for publication September 2, 1994; revision accepted September 17, 1995. We thank Dr. Janet Baer for providing veterinary support and Ms. Mimi Sengupta for research assistance. Funding was provided by the Human Brain Program (DA/MH 08944), the Shannon Award (NIA IR55-AG10283-01A1 and NIMH 5-R37-MH39145) to C.A.M., and the Caltech Summer Undergraduate Research Fellowship (SURF 1993) to J.T.L.
Funders:
Funding AgencyGrant Number
Human Brain ProjectDA/MH 08944
Shannon AwardIR55-AG10283-01A1
NIH5-R37-MH39145
Caltech Summer Undergraduate Research Fellowship (SURF)UNSPECIFIED
Subject Keywords:brain tumor; lipids; diet; captivity
Issue or Number:4
Record Number:CaltechAUTHORS:20200114-151646549
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200114-151646549
Official Citation:Lee, J.T., Miller, C.A., McDonald, C.T. and Allman, J.M. (1996), Xanthogranuloma of the choroid plexus in the fat‐tailed dwarf lemur (Cheirogaleus medius). Am. J. Primatol., 38: 349-355. doi:10.1002/(SICI)1098-2345(1996)38:4<349::AID-AJP5>3.0.CO;2-Z
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:100724
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Jan 2020 00:33
Last Modified:15 Jan 2020 00:33

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