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Electrophysiological Responses in the Human Amygdala Discriminate Emotion Categories of Complex Visual Stimuli

Oya, Hiroyuki and Kawasaki, Hiroto and Howard, Matthew A. and Adolphs, Ralph (2002) Electrophysiological Responses in the Human Amygdala Discriminate Emotion Categories of Complex Visual Stimuli. Journal of Neuroscience, 22 (21). pp. 9502-9512. ISSN 0270-6474. PMCID PMC6758059. doi:10.1523/jneurosci.22-21-09502.2002. https://resolver.caltech.edu/CaltechAUTHORS:20200124-160819105

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Abstract

The human amygdala has been shown to participate in processing emotionally salient stimuli related to threat, danger, and aversion, data that have come primarily from functional imaging and lesion studies. Recording intracranial field potentials from five amygdalas in four patients with chronically implanted depth electrodes, we analyzed responses in the gamma frequency range, a region of the power spectrum thought to reflect especially the contribution of neuronal activity to cognitive processes. Significant changes in the power amplitude of responses were obtained selectively to visual images judged to look aversive but not to those judged to look pleasant or neutral. Several possible confounds were addressed: all four patients had been carefully selected so that the amygdalas from which recordings were obtained were distal to epileptogenic foci, making it likely that we recorded from healthy tissue, and the observed responses could not be attributed to luminance or color differences between the stimuli. A further analysis of differences in power between the high and low gamma bands revealed an additional structure that discriminated those stimuli related to bodily injury from those related to disgust. Despite the increased power amplitude in the gamma range, there was no stimulus-locked phase coherence. The observed responses in the gamma frequency range may reflect the role of the amygdala in binding perceptual representations of the stimuli with memory, emotional response, and modulation of ongoing cognition, on the basis of the emotional significance of the stimuli.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/jneurosci.22-21-09502.2002DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758059PubMed CentralArticle
ORCID:
AuthorORCID
Oya, Hiroyuki0000-0002-1733-5478
Kawasaki, Hiroto0000-0002-7688-9171
Adolphs, Ralph0000-0002-8053-9692
Additional Information:© 2002 Society for Neuroscience. Received April 3, 2002; revised Aug. 12, 2002; accepted Aug. 12, 2002. This work was supported by grants from the EJLB Foundation, the Klingenstein Fund, and the James S. McDonnell Foundation. We thank Igor Volkov, Olaf Kaufman, Yota Kimura, and Soman Puzhankara for help with the experiments and data analysis, Mark Granner for providing epilepsy center services, and Daniel Tranel and Natalie Denburg for help with background neuropsychological testing.
Funders:
Funding AgencyGrant Number
EJLB FoundationUNSPECIFIED
Klingenstein FundUNSPECIFIED
James S. McDonnell FoundationUNSPECIFIED
Subject Keywords:amygdala; human; intracranial recording; local field potential; gamma oscillation; emotion
Issue or Number:21
PubMed Central ID:PMC6758059
DOI:10.1523/jneurosci.22-21-09502.2002
Record Number:CaltechAUTHORS:20200124-160819105
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200124-160819105
Official Citation:Electrophysiological Responses in the Human Amygdala Discriminate Emotion Categories of Complex Visual Stimuli. Hiroyuki Oya, Hiroto Kawasaki, Matthew A. Howard, Ralph Adolphs. Journal of Neuroscience 1 November 2002, 22 (21) 9502-9512; DOI: 10.1523/JNEUROSCI.22-21-09502.2002
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:100921
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Jan 2020 14:40
Last Modified:16 Nov 2021 17:57

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