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Resolution enhancement of transmission electron microscopy by super-resolution radial fluctuations

Zhang, Y. and Rouvimov, S. and Yuan, X. and Gonzalez-Serrano, K. and Seabaugh, A. C. and Howard, S. S. (2020) Resolution enhancement of transmission electron microscopy by super-resolution radial fluctuations. Applied Physics Letters, 116 (4). Art. No. 044105. ISSN 0003-6951. https://resolver.caltech.edu/CaltechAUTHORS:20200128-112042415

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Abstract

Super-resolution fluorescence microscopy techniques have enabled dramatic development in modern biology due to their capability to discern features smaller than the diffraction limit of light. Recently, super-resolution radial fluctuations (SRRF), an analytical approach that is capable of generating super-resolution images easily without the need for specialized hardware or photoswitchable fluorophores, has been presented. While SRRF has only been demonstrated on fluorescence microscopes, in principle, this method can be used to generate super-resolution images on any imaging platforms with intrinsic radial symmetric point spread functions. In this work, we show that SRRF can be utilized to enhance the resolution and quality of transmission electron microscopy (TEM) images. By including an image registration algorithm to correct for sample drift, the SRRF-TEM approach substantially enhances the resolution of TEM images of three different samples acquired with a commercial TEM system. We quantify the resolution improvement in SRRF-TEM and evaluate how SRRF parameters affect the resolution and quality of SRRF-TEM results.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1063/1.5128353DOIArticle
ORCID:
AuthorORCID
Zhang, Y.0000-0002-9463-3970
Seabaugh, A. C.0000-0001-6907-4129
Howard, S. S.0000-0003-3246-6799
Additional Information:© 2020 Published under license by AIP Publishing. Submitted: 18 September 2019; Accepted: 16 January 2020; Published Online: 28 January 2020. The authors thank Greg Pitner and Philip Wong (Stanford University) for providing the CNTs imaged here. This material is based upon the work supported by the National Science Foundation under Grant No. CBET-1554516.
Funders:
Funding AgencyGrant Number
NSFCBET-1554516
Issue or Number:4
Record Number:CaltechAUTHORS:20200128-112042415
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200128-112042415
Official Citation:Resolution enhancement of transmission electron microscopy by super-resolution radial fluctuations. Y. Zhang, S. Rouvimov, X. Yuan, K. Gonzalez-Serrano, A. C. Seabaugh, and S. S. Howard. Applied Physics Letters 116:4; doi: 10.1063/1.5128353
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:100962
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Jan 2020 19:25
Last Modified:28 Jan 2020 19:25

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