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Nanoscale Heat Transfer from Magnetic Nanoparticles and Ferritin in an Alternating Magnetic Field

Davis, Hunter C. and Kang, Sunghwi and Lee, Jae-Hyun and Shin, Tae-Hyun and Putterman, Harry and Cheon, Jinwoo and Shapiro, Mikhail G. (2020) Nanoscale Heat Transfer from Magnetic Nanoparticles and Ferritin in an Alternating Magnetic Field. Biophysical Journal, 118 (6). pp. 1502-1510. ISSN 0006-3495. PMCID PMC7091488 . https://resolver.caltech.edu/CaltechAUTHORS:20200203-092720672

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Abstract

Recent suggestions of nanoscale heat confinement on the surface of synthetic and biogenic magnetic nanoparticles during heating by radio frequency-alternating magnetic fields have generated intense interest because of the potential utility of this phenomenon for noninvasive control of biomolecular and cellular function. However, such confinement would represent a significant departure from the classical heat transfer theory. Here, we report an experimental investigation of nanoscale heat confinement on the surface of several types of iron oxide nanoparticles commonly used in biological research, using an all-optical method devoid of the potential artifacts present in previous studies. By simultaneously measuring the fluorescence of distinct thermochromic dyes attached to the particle surface or dissolved in the surrounding fluid during radio frequency magnetic stimulation, we found no measurable difference between the nanoparticle surface temperature and that of the surrounding fluid for three distinct nanoparticle types. Furthermore, the metalloprotein ferritin produced no temperature increase on the protein surface nor in the surrounding fluid. Experiments mimicking the designs of previous studies revealed potential sources of the artifacts. These findings inform the use of magnetic nanoparticle hyperthermia in engineered cellular and molecular systems.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.bpj.2020.01.028DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7091488/PubMed CentralArticle
ORCID:
AuthorORCID
Davis, Hunter C.0000-0003-1655-692X
Shapiro, Mikhail G.0000-0002-0291-4215
Additional Information:© 2020 Biophysical Society. Received 11 November 2019, Accepted 21 January 2020, Available online 1 February 2020. The authors thank Polina Anikeeva, Arnd Pralle, Michael Christiansen, George Varnavides, Pradeep Ramesh, and Markus Meister for helpful discussions and Yuxing Yao for assistance with electron microscopy. This research was supported by the Burroughs Wellcome Career Award at the Scientific Interface, the Packard Fellowship in Science and Engineering, the Rosen Center for Bioengineering, and the Center for Environmental Microbial Interactions at Caltech. Author Contributions: H.C.D. and M.G.S. conceived the study. H.C.D. constructed the experimental apparatus, prepared the reagents, acquired the data, and analyzed the data. H.P. assisted in apparatus construction and data acquisition. S.K., J.-H.L., T.-H.S., and J.C. synthesized and functionalized magnetic nanoparticles. H.C.D. and M.G.S. wrote the manuscript with input from all other authors. M.G.S. supervised the research.
Group:Caltech Center for Environmental Microbial Interactions (CEMI), Rosen Bioengineering Center
Funders:
Funding AgencyGrant Number
Burroughs Wellcome FundUNSPECIFIED
David and Lucile Packard FoundationUNSPECIFIED
Donna and Benjamin M. Rosen Bioengineering CenterUNSPECIFIED
Caltech Center for Environmental Microbial Interactions (CEMI)UNSPECIFIED
Issue or Number:6
PubMed Central ID:PMC7091488
Record Number:CaltechAUTHORS:20200203-092720672
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200203-092720672
Official Citation:Hunter C. Davis, Sunghwi Kang, Jae-Hyun Lee, Tae-Hyun Shin, Harry Putterman, Jinwoo Cheon, Mikhail G. Shapiro, Nanoscale Heat Transfer from Magnetic Nanoparticles and Ferritin in an Alternating Magnetic Field, Biophysical Journal, Volume 118, Issue 6, 2020, Pages 1502-1510, ISSN 0006-3495, https://doi.org/10.1016/j.bpj.2020.01.028. (http://www.sciencedirect.com/science/article/pii/S0006349520301016)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:101055
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:03 Feb 2020 18:48
Last Modified:02 Apr 2020 17:29

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