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Minor early embryonic chick hemoglobin M. Amino acid sequences of the epsilon and alpha D chains

Chapman, Barbara S. and Hood, Leroy E. and Tobin, Allan J. (1982) Minor early embryonic chick hemoglobin M. Amino acid sequences of the epsilon and alpha D chains. Journal of Biological Chemistry, 257 (2). pp. 651-658. ISSN 0021-9258.

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Erythrocytes of the early chick embryo contain four hemoglobins, two major and two minor. In this paper, we present amino acid sequences for the beta-like and alpha-like chains of HbM, the least abundant of the four early chick hemoglobins. The complete amino acid sequence of the beta-like chain of HbM is identical with that of the epsilon chain of HbE, the other minor early embryonic hemoglobin in the domestic chicken. Analysis of the alpha-like chain of HbM (92 of 141 residues) reveals a globin sequence closely related to the minor adult alpha D chain. Comparison of our sequence data with the nucleotide sequence of the alpha D globin gene suggests that a single gene encodes both the embryonic and adult alpha D globin polypeptides. We discuss the structure, possible function, and evolution of the HbM globin chains.

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Hood, Leroy E.0000-0001-7158-3678
Additional Information:Copyright © 1982 by the American Society for Biochemistry and Molecular Biology. (Received for publication, June 3, 1981) We thank Dr. Allan Wilson for sharing his stock of bird lore, and for giving us comments that greatly improved this manuscript. We also thank Sandra Martin for useful discussions. Margaret Kowalszyk’s careful illustrations are greatly appreciated. We are grateful to Drs. J.D. Engel and J.B. Dodgson for many lively discussions and for sharing with us their unpublished manuscripts. []B.S.C. was the] [r]ecipient of National Research Service Award HL05553. [L.E.H. was the] [r]ecipient of Grant GM-06965 from the National Institutes of Health. [A.J.T. was the] [r]ecipient of National Science Foundation Grants PCM 76-02859 and PCM 78-20767. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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ID Code:10114
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Deposited On:14 Apr 2008
Last Modified:03 Mar 2020 13:01

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