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Nucleoporin Condensates Drive Nuclear Pore Complex Assembly in Oocytes

Mobbs, George W. and Hoelz, André (2020) Nucleoporin Condensates Drive Nuclear Pore Complex Assembly in Oocytes. Trends in Biochemical Sciences, 45 (4). pp. 278-280. ISSN 0968-0004. PMCID PMC7505689.

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Oocytes stockpile nuclear pore complexes (NPCs) in cytoplasmic membrane sheets called annulate lamellae (AL) in preparation for rapid cell cycles during embryogenesis. Recently, Hampoelz et al. reported that AL–NPC assembly depends on the coordinated formation, transport, and interaction of biomolecular condensates containing distinct sets of nucleoporins.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Mobbs, George W.0000-0003-2405-3345
Hoelz, André0000-0003-1726-0127
Additional Information:© 2020 Elsevier Ltd. Available online 13 February 2020. We thank Alina Patke for help with editing of the manuscript and figure preparation. A.H. is an Investigator of the Heritage Medical Research Institute and a Faculty Scholar of the Howard Hughes Medical Institute and was supported by National Institutes of Health grants R01-GM111461 and R01-GM117360.
Group:Heritage Medical Research Institute
Funding AgencyGrant Number
Heritage Medical Research InstituteUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:nuclear pore complex; macromolecular assembly; annulate lamellae; oogenesis; nucleoporin liquid–liquid phase separation condensate
Issue or Number:4
PubMed Central ID:PMC7505689
Record Number:CaltechAUTHORS:20200213-082709014
Persistent URL:
Official Citation:George W. Mobbs, André Hoelz, Nucleoporin Condensates Drive Nuclear Pore Complex Assembly in Oocytes, Trends in Biochemical Sciences, Volume 45, Issue 4, 2020, Pages 278-280, ISSN 0968-0004, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:101264
Deposited By: Tony Diaz
Deposited On:13 Feb 2020 17:01
Last Modified:23 Sep 2020 16:23

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