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Selective proteomic analysis of cellular sub-populations in complex biological systems

Tirrell, David Anthony (2020) Selective proteomic analysis of cellular sub-populations in complex biological systems. In: 259th ACS National Meeting & Exposition, 22-26 March 2020, Philadelphia, PA.

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This lecture will describe the use of non-canonical amino acids (ncAAs) as selective probes of protein synthesis in complex biol. systems. Pulse-labeling with ncAA probes provides time-resoln., while controlled expression of mutant aminoacyl-tRNA synthetases allows the investigator to restrict anal. to cell types or cell states of interest. The methods are applicable to studies of microbial systems, mammalian cell culture, and a variety of animal models. The scope and limitations of the approach, and some of our most recent results, will be discussed.

Item Type:Conference or Workshop Item (Paper)
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Tirrell, David Anthony0000-0003-3175-4596
Additional Information:© 2020 American Chemical Society.
Record Number:CaltechAUTHORS:20200219-084532646
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:101365
Deposited By: Tony Diaz
Deposited On:19 Feb 2020 17:40
Last Modified:19 Feb 2020 17:40

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