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Genome editing in non-model organisms opens new horizons for comparative physiology

Dickinson, Michael H. and Vosshall, Leslie B. and Dow, Julian A. T. (2020) Genome editing in non-model organisms opens new horizons for comparative physiology. Journal of Experimental Biology, 223 (Suppl 1). p. 1. ISSN 0022-0949. https://resolver.caltech.edu/CaltechAUTHORS:20200219-103200881

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Abstract

For almost 100 years, biologists have made fundamental discoveries using a handful of model organisms that are not representative of the rich diversity found in nature. The advent of CRISPR genome editing now opens up a wide range of new organisms to mechanistic investigation. This increases not only the taxonomic breadth of current research but also the scope of biological problems that are now amenable to study, such as population control of invasive species, management of disease vectors such as mosquitoes, the creation of chimeric animal hosts to grow human organs and even the possibility of resurrecting extinct species such as passenger pigeons and mammoths. Beyond these practical applications, work on non-model organisms enriches our basic understanding of the natural world. This special issue addresses a broad spectrum of biological problems in non-model organisms and highlights the utility of genome editing across levels of complexity from development and physiology to behaviour and evolution.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1242/jeb.221119DOIArticle
ORCID:
AuthorORCID
Dickinson, Michael H.0000-0002-8587-9936
Vosshall, Leslie B.0000-0002-6060-8099
Dow, Julian A. T.0000-0002-9595-5146
Additional Information:© 2020 Published by The Company of Biologists Ltd.
Issue or Number:Suppl 1
Record Number:CaltechAUTHORS:20200219-103200881
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200219-103200881
Official Citation:Genome editing in non-model organisms opens new horizons for comparative physiology. Michael H. Dickinson, Leslie B. Vosshall, Julian A. T. Dow. Journal of Experimental Biology 2020 223: jeb221119 doi: 10.1242/jeb.221119. Published 7 February 2020
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:101374
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 Feb 2020 18:37
Last Modified:19 Feb 2020 18:37

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