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Enantioselective C-H amination via directed evolution of cytochrome P450 enzymes

Yang, Yang and Arnold, Frances Hamilton (2020) Enantioselective C-H amination via directed evolution of cytochrome P450 enzymes. In: 259th ACS National Meeting & Exposition, 22-26 March 2020, Philadelphia, PA.

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The selective functionalization of ubiquitous C-H bonds can greatly streamline the construction of complex mol. architectures from easily available precursors. In particular, the development of general systems for the regio- and enantioselective transformation of C-H bonds lies at the forefront of current efforts to further advance transition-metalcatalyzed C-H functionalization. In this talk, I will discuss recent work from the Arnold lab at Caltech on using engineered cytochromes P 450 for C-H amination processes. These genetically encoded enzymes are produced and function in bacteria, where they can be easily optimized by directed evolution. With this biocatalytic platform, a range of challenging C-H amination processes can be accomplished with excellent total turnover nos. in a regio- and stereocontrolled fashion.

Item Type:Conference or Workshop Item (Paper)
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URLURL TypeDescription Website
Yang, Yang0000-0002-4956-2034
Arnold, Frances Hamilton0000-0002-4027-364X
Additional Information:© 2020 American Chemical Society.
Record Number:CaltechAUTHORS:20200219-144552998
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:101398
Deposited By: Tony Diaz
Deposited On:19 Feb 2020 23:01
Last Modified:19 Feb 2020 23:01

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