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The representation of finger movement and force in human motor and premotor cortices

Flint, Robert D. and Tate, Matthew C. and Li, Kejun and Templer, Jessica W. and Rosenow, Joshua M. and Pandarinath, Chethan and Slutzky, Marc W. (2020) The representation of finger movement and force in human motor and premotor cortices. eNeuro, 7 (4). pp. 1-15. ISSN 2373-2822. PMCID PMC7438059. https://resolver.caltech.edu/CaltechAUTHORS:20200220-114026016

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Abstract

The ability to grasp and manipulate objects requires controlling both finger movement kinematics and isometric force in rapid succession. Previous work suggests that these behavioral modes are controlled separately, but it is unknown whether the cerebral cortex represents them differently. Here, we asked the question of how movement and force were represented cortically, when executed sequentially with the same finger. We recorded high-density electrocorticography (ECoG) from the motor and premotor cortices of seven human subjects performing a movement-force motor task. We decoded finger movement [0.7 ± 0.3 fractional variance accounted for (FVAF)] and force (0.7 ± 0.2 FVAF) with high accuracy, yet found different spatial representations. In addition, we used a state-of-the-art deep learning method to uncover smooth, repeatable trajectories through ECoG state space during the movement-force task. We also summarized ECoG across trials and participants by developing a new metric, the neural vector angle (NVA). Thus, state-space techniques can help to investigate broad cortical networks. Finally, we were able to classify the behavioral mode from neural signals with high accuracy (90 ± 6%). Thus, finger movement and force appear to have distinct representations in motor/premotor cortices. These results inform our understanding of the neural control of movement, as well as the design of grasp brain-machine interfaces (BMIs).


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/ENEURO.0063-20.2020DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7438059/PubMed CentralArticle
https://doi.org/10.1101/2020.02.18.952945DOIDiscussion Paper
ORCID:
AuthorORCID
Flint, Robert D.0000-0002-0281-5778
Slutzky, Marc W.0000-0003-2269-7729
Alternate Title:Distinct representations of finger movement and force in human motor and premotor cortices
Additional Information:© 2020 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Received February 19, 2020; accepted May 21, 2020; First published August 3, 2020. We thank our research subjects for their participation and Mukta Vaidya for helpful comments on this manuscript. This work was supported by the Craig H. Neilsen Foundation Fellowship (R.D.F.); an Emory College Computational Neuroscience training grant (K.L.); Burroughs Wellcome Fund Collaborative Research Travel Grant (C.P.); the National Science Foundation Grant NCS 1835364 (to C.P.); the Emory Neuromodulation Technology Innovation Center (C.P.); the Doris Duke Charitable Foundation Clinical Scientist Development Award (M.W.S.); The Northwestern Memorial Foundation Dixon Translational Research Grant Program, supported in part by National Institutes of Health (NIH) Grant UL1RR025741 (to M.W.S.); the Department of Health and Human Services NIH Grant R01NS094748 (to M.W.S.). Author contributions: R.D.F. and M.W.S. designed research; R.D.F., M.C.T., J.W.T., J.M.R., and M.W.S. performed research; R.D.F., K.L., C.P., and M.W.S. analyzed data; R.D.F., K.L., C.P., and M.W.S. wrote the paper. The authors declare no competing financial interests.
Funders:
Funding AgencyGrant Number
Craig H. Neilsen FoundationUNSPECIFIED
Emory CollegeUNSPECIFIED
Burroughs Wellcome FundUNSPECIFIED
NSFIIS-1835364
Doris Duke Charitable FoundationUNSPECIFIED
Northwestern UniversityUNSPECIFIED
NIHUL1RR025741
NIHR01NS094748
Subject Keywords:Cortex; Electrocorticography; Grasp; Human; Kinematic; Kinetic
Issue or Number:4
PubMed Central ID:PMC7438059
Record Number:CaltechAUTHORS:20200220-114026016
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200220-114026016
Official Citation:The Representation of Finger Movement and Force in Human Motor and Premotor Cortices. Robert D. Flint, Matthew C. Tate, Kejun Li, Jessica W. Templer, Joshua M. Rosenow, Chethan Pandarinath, Marc W. Slutzky. eNeuro 7 August 2020, 7 (4) ENEURO.0063-20.2020; DOI: 10.1523/ENEURO.0063-20.2020
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:101421
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Feb 2020 21:32
Last Modified:21 Aug 2020 16:38

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