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In vivo super-resolution photoacoustic computed tomography by localization of single dyed droplets

Li, Lei and Zhang, Pengfei and Wang, Lihong V. (2020) In vivo super-resolution photoacoustic computed tomography by localization of single dyed droplets. In: Photons Plus Ultrasound: Imaging and Sensing 2020. Proceedings of SPIE. No.11240. Society of Photo-Optical Instrumentation Engineers (SPIE) , Art. No. 112402U. ISBN 9781510632431. https://resolver.caltech.edu/CaltechAUTHORS:20200220-132155264

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Abstract

The spatial resolution of photoacoustic (PA) computed tomography (PACT) is limited by acoustic diffraction. Here, we report in vivo superresolution PACT, which breaks the acoustic diffraction limit by localizing the centers of single dyed droplets. The dyed droplets generate much stronger PA signals than blood and can flow smoothly in blood vessels; thus, they are excellent tracers for localization-based superresolution imaging. The flowing droplets were first localized, and then their center positions were used to construct a superresolution image that exhibits sharper features and more finely resolved vascular details. A 6-fold improvement in spatial resolution has been realized in vivo.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2547562DOIArticle
ORCID:
AuthorORCID
Li, Lei0000-0001-6164-2646
Zhang, Pengfei0000-0002-4226-1394
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2020 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was sponsored by the NIH grants DP1 EB016986 (NIH Director’s Pioneer Award), R01 CA186567 (NIH Director’s Transformative Research Award), U01 NS090579 (BRAIN Initiative), and U01 NS099717 (BRAIN Initiative). L.W. has a financial interest in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which, however, did not support this work. The other authors declare no conflict of interest.
Funders:
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
NIHU01 NS090579
NIHU01 NS099717
Subject Keywords:Photoacoustic computed tomography; super-resolution; localization; single dyed droplets
Series Name:Proceedings of SPIE
Issue or Number:11240
Record Number:CaltechAUTHORS:20200220-132155264
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200220-132155264
Official Citation:Lei Li, Pengfei Zhang, and Lihong V. Wang "In vivo super-resolution photoacoustic computed tomography by localization of single dyed droplets", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112402U (17 February 2020); https://doi.org/10.1117/12.2547562
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:101424
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Feb 2020 21:28
Last Modified:20 Feb 2020 21:28

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