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Photoacoustic computed tomography guided microrobots for targeted navigation in intestines in vivo

Li, Lei and Wu, Zhiguang and Yang, Yiran and Hu, Peng and Gao, Wei and Wang, Lihong V. (2020) Photoacoustic computed tomography guided microrobots for targeted navigation in intestines in vivo. In: Photons Plus Ultrasound: Imaging and Sensing 2020. Proceedings of SPIE. No.11240. Society of Photo-Optical Instrumentation Engineers (SPIE) , Art. No. 112402R. ISBN 9781510632431. https://resolver.caltech.edu/CaltechAUTHORS:20200220-134102759

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Abstract

Tremendous progress in synthetic micro/nanomotors has been made for potential biomedical applications. However, existing micro/nanomotor platforms are inefficient for deep tissue imaging and motion control in vivo. Here, we present a photoacoustic computed tomography (PACT) guided investigation of micromotors in intestines in vivo. The micromotors enveloped in microcapsules exhibit efficient propulsion in various biofluids once released. PACT has visualized the migration of micromotor capsules toward the targeted regions in real time in vivo. The integration of the developed microrobotic system and PACT enables deep imaging and precise control of the micromotors in vivo.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2547559DOIArticle
ORCID:
AuthorORCID
Li, Lei0000-0001-6164-2646
Yang, Yiran0000-0001-8770-8746
Hu, Peng0000-0002-2933-1239
Gao, Wei0000-0002-8503-4562
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2020 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was sponsored by the Startup funds from California Institute of Technology (to W.G.) and the NIH grants EB016986 (NIH Director’s Pioneer Award), CA186567 (NIH Director’s Transformative Research Award), NS090579, and NS099717 (all to L.V.W.). We gratefully acknowledge critical support and infrastructure provided for this work by the Kavli Nanoscience Institute at Caltech.
Group:Kavli Nanoscience Institute
Funders:
Funding AgencyGrant Number
CaltechUNSPECIFIED
NIHDP1 EB016986
NIHCA186567
NIHNS090579
NIHNS099717
Subject Keywords:Photoacoustic computed tomography; microrobots; in vivo navigation
Series Name:Proceedings of SPIE
Issue or Number:11240
Record Number:CaltechAUTHORS:20200220-134102759
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200220-134102759
Official Citation:Lei Li, Zhiguang Wu, Yiran Yang, Peng Hu, Wei Gao, and Lihong V. Wang "Photoacoustic computed tomography guided microrobots for targeted navigation in intestines in vivo", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112402R (17 February 2020); https://doi.org/10.1117/12.2547559
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:101427
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Feb 2020 21:48
Last Modified:20 Feb 2020 21:48

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