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Increased hippocampal shape asymmetry and volumetric ventricular asymmetry in autism spectrum disorder

Richards, Rose and Greimel, Ellen and Kliemann, Dorit and Koerte, Inga K. and Schulte-Körne, Gerd and Reuter, Martin and Wachinger, Christian (2020) Increased hippocampal shape asymmetry and volumetric ventricular asymmetry in autism spectrum disorder. NeuroImage: Clinical, 26 . Art. No. 102207. ISSN 2213-1582. PMCID PMC7037573. https://resolver.caltech.edu/CaltechAUTHORS:20200224-110103855

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Abstract

Autism spectrum disorder (ASD) is a prevalent and fast-growing pervasive neurodevelopmental disorder worldwide. Despite the increasing prevalence of ASD and the breadth of research conducted on the disorder, a conclusive etiology has yet to be established and controversy still exists surrounding the anatomical abnormalities in ASD. In particular, structural asymmetries have seldom been investigated in ASD, especially in subcortical regions. Additionally, the majority of studies for identifying structural biomarkers associated with ASD have focused on small sample sizes. Therefore, the present study utilizes a large-scale, multi-site database to investigate asymmetries in the amygdala, hippocampus, and lateral ventricles, given the potential involvement of these regions in ASD. Contrary to prior work, we are not only computing volumetric asymmetries, but also shape asymmetries, using a new measure of asymmetry based on spectral shape descriptors. This measure represents the magnitude of the asymmetry and therefore captures both directional and undirectional asymmetry. The asymmetry analysis is conducted on 437 individuals with ASD and 511 healthy controls using T1-weighted MRI scans from the Autism Brain Imaging Data Exchange (ABIDE) database. Results reveal significant asymmetries in the hippocampus and the ventricles, but not in the amygdala, in individuals with ASD. We observe a significant increase in shape asymmetry in the hippocampus, as well as increased volumetric asymmetry in the lateral ventricles in individuals with ASD. Asymmetries in these regions have not previously been reported, likely due to the different characterization of neuroanatomical asymmetry and smaller sample sizes used in previous studies. Given that these results were demonstrated in a large cohort, such asymmetries may be worthy of consideration in the development of neurodiagnostic classification tools for ASD.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.nicl.2020.102207DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7037573/PubMed CentralArticle
ORCID:
AuthorORCID
Richards, Rose0000-0003-4175-2279
Additional Information:© 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/). Received 18 March 2019, Revised 20 January 2020, Accepted 3 February 2020, Available online 5 February 2020. This work was supported in part by the Faculty of Medicine at LMU (FöFoLe) and the Bavarian State Ministry of Science and the Arts in the framework of the Centre Digitisation.Bavaria (ZD.B).
Funders:
Funding AgencyGrant Number
Ludwig-Maximilian-UniversityUNSPECIFIED
Bavarian State Ministry of Science and the ArtsUNSPECIFIED
Subject Keywords:Autism; Asymmetry; MRI; Amygdala; Hippocampus; Ventricles
PubMed Central ID:PMC7037573
Record Number:CaltechAUTHORS:20200224-110103855
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200224-110103855
Official Citation:Rose Richards, Ellen Greimel, Dorit Kliemann, Inga K. Koerte, Gerd Schulte-Körne, Martin Reuter, Christian Wachinger, Increased hippocampal shape asymmetry and volumetric ventricular asymmetry in autism spectrum disorder, NeuroImage: Clinical, Volume 26, 2020, 102207, ISSN 2213-1582, https://doi.org/10.1016/j.nicl.2020.102207. (http://www.sciencedirect.com/science/article/pii/S2213158220300449)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:101491
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Feb 2020 20:53
Last Modified:02 Apr 2020 17:21

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