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Atypical Neural Responses During Face Processing in Female Adolescents With Conduct Disorder

Fairchild, Graeme and Hagan, Cindy C. and Passamonti, Luca and Walsh, Nicholas D. and Goodyer, Ian M. and Calder, Andrew J. (2014) Atypical Neural Responses During Face Processing in Female Adolescents With Conduct Disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 53 (6). pp. 677-687. ISSN 0890-8567. PMCID PMC4032577. https://resolver.caltech.edu/CaltechAUTHORS:20200225-135945127

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Abstract

Objective: Conduct disorder (CD) in females is associated with negative adult outcomes including mental health problems and personality disorders. Although recent neuroimaging studies have reported changes in neural activity during facial emotion processing in males with CD or callous-unemotional (CU) traits, there have been no neuroimaging studies specifically assessing females with CD. We addressed this gap by investigating whether female adolescents with CD show atypical neural activation when processing emotional or neutral faces. Method: We acquired functional magnetic resonance imaging (fMRI) data from 20 female adolescents with CD and 20 female control participants while they viewed angry, sad, and neutral faces. Results: An omnibus group (CD, control) by facial emotion (angry, sad, neutral) analysis of variance (ANOVA) revealed main effects of facial emotion in superior temporal cortex, fusiform gyrus, ventrolateral prefrontal cortex and insula, and main effects of group in medial orbitofrontal cortex (OFC) and right anterior insula. Female participants with CD showed reduced medial OFC and increased anterior insula responses relative to healthy controls. There were no significant group × facial emotion interactions. Lifetime CD symptoms were negatively correlated with amygdala, superior temporal cortex, fusiform gyrus, and dorsolateral prefrontal cortex activity for the contrast “all-faces versus fixation.” CU traits were negatively correlated with fusiform gyrus activity for the contrast sad versus neutral faces. Conclusion: Females with CD showed atypical neural activation during the processing of all facial expressions, irrespective of valence. Our results demonstrate that severity of CD symptoms and CU traits is important in explaining abnormal patterns of neural activity.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.jaac.2014.02.009DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4032577/PubMed CentralArticle
ORCID:
AuthorORCID
Fairchild, Graeme0000-0001-7814-9938
Hagan, Cindy C.0000-0002-4576-7120
Additional Information:© 2014 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Under a Creative Commons license (Attribution 4.0 International (CC BY 4.0)) Accepted 5 March 2014, Available online 11 March 2014. This article was reviewed under and accepted by deputy editor Ellen Leibenluft, M.D. This research was funded by project grant 083140 from the Wellcome Trust (G.F. and I.M.G.) and Medical Research Council project code MC_US_A060_5PQ50 (A.J.C.). This work was completed within the National Institute of Health Research Collaboration for Leadership in Applied Health Research and Care for Cambridgeshire and Peterborough. Rik Henson, PhD, of University of Cambridge served as a consultant on the design of the functional magnetic resonance imaging task. Disclosures: Drs. Fairchild, Hagan, Passamonti, Walsh, Goodyer, and Calder report no biomedical financial interests or potential conflicts of interest.
Funders:
Funding AgencyGrant Number
Wellcome Trust083140
Medical Research Council (UK)MC_US_A060_5PQ50
Subject Keywords:CD; CU traits; females; face processing; fMRI
Issue or Number:6
PubMed Central ID:PMC4032577
Record Number:CaltechAUTHORS:20200225-135945127
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200225-135945127
Official Citation:Graeme Fairchild, Cindy C. Hagan, Luca Passamonti, Nicholas D. Walsh, Ian M. Goodyer, Andrew J. Calder, Atypical Neural Responses During Face Processing in Female Adolescents With Conduct Disorder, Journal of the American Academy of Child & Adolescent Psychiatry, Volume 53, Issue 6, 2014, Pages 677-687.e5, ISSN 0890-8567, https://doi.org/10.1016/j.jaac.2014.02.009.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:101561
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:26 Feb 2020 16:04
Last Modified:09 Mar 2020 13:18

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