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Functional MRI of emotional memory in adolescent depression

Holt, Rosemary J. and Graham, Julia M. and Whitaker, Kirstie J. and Hagan, Cindy C. and Ooi, Cinly and Wilkinson, Paul O. and van Nieuwenhuizen, Adrienne O. and Lennox, Belinda R. and Sahakian, Barbara J. and Goodyer, Ian M. and Bullmore, Edward T. and Suckling, John (2016) Functional MRI of emotional memory in adolescent depression. Developmental Cognitive Neuroscience, 19 . pp. 31-41. ISSN 1878-9293. PMCID PMC4913558. doi:10.1016/j.dcn.2015.12.013.

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Introduction: Major Depressive Disorder (MDD) is a leading cause of disease burden worldwide. Mood-congruent biases in memory tasks are frequently reported in MDD patients, with facilitated memory for negative stimuli. Most functional MRI studies to date have examined the neural correlates of these biases in depressed adults, with fewer studies in adolescents with MDD. Investigation of MDD in adolescence may aid greater understanding of the aetiology and development of the disorder. Methods: Cognitive biases were investigated in 56 MDD patients aged 11–17 years and a matched group of 30 healthy control participants with a self-referential memory task. Behavioural performance and BOLD fMRI data were collected during both encoding and retrieval stages. Results: The neural response to encoding in adolescents with MDD was found to differ significantly from controls. Additionally, neural responses during encoding and retrieval showed differential relationships with age between patient and control groups, specifically in medial, temporal, and prefrontal regions. Conclusions: These findings suggest that during adolescence neurophysiological activity associated with emotional memory differs in those with depression compared to controls and may be age sensitive.

Item Type:Article
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Hagan, Cindy C.0000-0002-4576-7120
Additional Information:© 2016 The Authors. Published by Elsevier Under a Creative Commons license (Attribution 4.0 International (CC BY 4.0)) Received 23 December 2014, Revised 22 December 2015, Accepted 23 December 2015, Available online 31 December 2015. This study was funded by the UK Medical Research Council (MRC) (G0802226) and the Behavioural and Clinical Neuroscience Institute (BCNI) at the University of Cambridge (jointly funded by the MRC and Wellcome Trust). Additional support was given by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre. We thank the participants and their families for taking part in the study. We would also like to thank the Cambridge and Peterborough NHS Foundation trust, Child and Adolescent Mental Health services and members of the IMPACT team. We are grateful to Rebecca Eliot for her advice on the analysis design. RJ Holt and JM Graham contributed equally to this paper. Conflict of interest: ETB is employed half time by the University of Cambridge and half time by GlaxoSmithKline plc. BJS consults for Cambridge Cognition, Servier, Otsuka, Peak (Brainbow) and Lundbeck; she holds a grant from Janssen/J&J. The other authors report no biomedical financial interests or conflicts of interest.
Funding AgencyGrant Number
Medical Research Council (UK)G0802226
National Institute for Health ResearchUNSPECIFIED
Cambridge and Peterborough Mental Health TrustUNSPECIFIED
Subject Keywords:Depression; Adolescence; Memory; fMRI; Emotion
PubMed Central ID:PMC4913558
Record Number:CaltechAUTHORS:20200225-135945672
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Official Citation:Rosemary J. Holt, Julia M. Graham, Kirstie J. Whitaker, Cindy C. Hagan, Cinly Ooi, Paul O. Wilkinson, Adrienne O. van Nieuwenhuizen, Belinda R. Lennox, Barbara J. Sahakian, Ian M. Goodyer, Edward T. Bullmore, John Suckling, Functional MRI of emotional memory in adolescent depression, Developmental Cognitive Neuroscience, Volume 19, 2016, Pages 31-41, ISSN 1878-9293,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:101566
Deposited By: George Porter
Deposited On:26 Feb 2020 15:43
Last Modified:16 Nov 2021 18:03

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