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The long terminal repeat is not a major determinant of the cellular tropism of human immunodeficiency virus type 1

Pomerantz, Roger J. and Feinberg, Mark B. and Andino, Raul and Baltimore, David (1991) The long terminal repeat is not a major determinant of the cellular tropism of human immunodeficiency virus type 1. Journal of Virology, 65 (2). pp. 1041-1045. ISSN 0022-538X.

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The long terminal repeats (LTRs) of human immunodeficiency virus type 1 (HIV-1) strains from the central nervous systems of four patients with AIDS and of an HIV-1 isolate which is highly macrophage-tropic were isolated by using the polymerase chain reaction. In transient transfection assays, these LTRs demonstrated no significant difference in basal or stimulated levels of transcription in any of a variety of cell lines tested, compared with expression directed from the LTR of a T-lymphocyte-tropic strain of HIV-1. Chimeric viruses were created with the LTRs of the macrophage-tropic and brain-derived viruses ligated to the viral backbone from a T-lymphocyte-tropic strain. No change in cellular tropism was demonstrated with these chimeric viruses. Thus, unlike the LTRs of some murine retroviruses, the LTR of HIV-1 does not appear to play a major role in determining cellular tropism.

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Baltimore, David0000-0001-8723-8190
Additional Information:Copyright © 1991 by the American Society for Microbiology. Received 27 August 1990/Accepted 15 November 1990. We would like to thank Didier Trono, Mark Muesing, Mark Schlissel, and Sunyoung Kim for helpful discussions and advice. We also thank Carl O'Hara and Jerry Groopman for providing tissue samples and Brian Conway for assistance with the monocyte/macrophage cultures. R.J.P. was funded under Physician Scientist Award no. A199030. This work was supported in part by Public Health Service grants A1226463 and HL43510.
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Deposited On:15 Apr 2008
Last Modified:03 Oct 2019 00:07

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