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On the mechanics of mucociliary flows. III. Flow-velocity profiles in frog palate mucus

Winet, H. and Yates, G. T. and Wu, T. Y. and Head, J. (1984) On the mechanics of mucociliary flows. III. Flow-velocity profiles in frog palate mucus. Journal of Applied Physiology, 56 (3). pp. 785-794. ISSN 8750-7587. doi:10.1152/jappl.1984.56.3.785.

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Flow-velocity profiles over excised frog ciliated epithelium were obtained for the region within about 600 micron of the mucosa. Fluorescent particles were used as flow tracers. Both a control and an autologous mucus suspension were observed. The control culture medium was bounded by the walls of the observation chamber, and mucus was deposited on the epithelium as a blob after mixing it with tracers. In spite of the difference in boundary conditions the two profiles, normalized to maximum particle velocity and solution depth, were indistinguishable at heights over 60 micron from the mucosa. The near-mucosa profiles in contrast were unalike with mucus exhibiting a greater shear gradient than the control culture medium. It was concluded that ciliary contact is not necessary for generation of mucus flow provided the ciliary shear is not negated by the mucus “flake” or “slab” being in simultaneous contact with significant ciliostatic patches which would act as anchors.

Item Type:Article
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Head, J.0000-0003-2013-560X
Additional Information:© 1984 the American Physiological Society. Received 15 March 1983; accepted in final form 29 September 1983. This work was supported by National Institutes of Health Grant HD-51442 and National Science Foundation Grant CME 77-21236.
Funding AgencyGrant Number
NSFCME 77-21236
Subject Keywords:mucocilia; fluorescent microspheres; frog ciliated epithelium; coumarin
Issue or Number:3
Record Number:CaltechAUTHORS:20200306-133728404
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Official Citation:On the mechanics of mucociliary flows. III. Flow-velocity profiles in frog palate mucus H. Winet, G. T. Yates, T. Y. Wu, and J. Head Journal of Applied Physiology 1984 56:3, 785-794
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:101750
Deposited By: George Porter
Deposited On:06 Mar 2020 21:48
Last Modified:16 Nov 2021 18:05

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