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Effects of Random External Background Stimulation on Network Synaptic Stability After Tetanization: A Modeling Study

Chao, Zenas C. and Bakkum, Douglas J. and Wagenaar, Daniel A. and Potter, Steve M. (2005) Effects of Random External Background Stimulation on Network Synaptic Stability After Tetanization: A Modeling Study. Neuroinformatics, 3 (3). pp. 263-280. ISSN 1539-2791. PMCID PMC2584804. doi:10.1385/ni:3:3:263. https://resolver.caltech.edu/CaltechAUTHORS:20200320-082655455

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Abstract

We constructed a simulated spiking neural network model to investigate the effects of random background stimulation on the dynamics of network activity patterns and tetanus induced network plasticity. The simulated model was a “leaky integrate-and-fire” (LIF) neural model with spike-timing-dependent plasticity (STDP) and frequency-dependent synaptic depression. Spontaneous and evoked activity patterns were compared with those of living neuronal networks cultured on multielectrode arrays. To help visualize activity patterns and plasticity in our simulated model, we introduced new population measures called Center of Activity (CA) and Center of Weights (CW) to describe the spatio-temporal dynamics of network-wide firing activity and network-wide synaptic strength, respectively. Without random background stimulation, the network synaptic weights were unstable and often drifted after tetanization. In contrast, with random background stimulation, the network synaptic weights remained close to their values immediately after tetanization. The simulation suggests that the effects of tetanization on network synaptic weights were difficult to control because of ongoing synchronized spontaneous bursts of action potentials, or “barrages.” Random background stimulation helped maintain network synaptic stability after tetanization by reducing the number and thus the influence of spontaneous barrages. We used our simulated network to model the interaction between ongoing neural activity, external stimulation and plasticity, and to guide our choice of sensory-motor mappings for adaptive behavior in hybrid neural-robotic systems or “hybrots.”


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1385/ni:3:3:263DOIArticle
https://rdcu.be/b288tPublisherFree ReadCube access
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584804PubMed CentralArticle
ORCID:
AuthorORCID
Wagenaar, Daniel A.0000-0002-6222-761X
Additional Information:© 2005 Humana Press Inc. Issue Date: September 2005. This work was partially supported by grants NS38628 from NIH/NINDS, and EB000786 from NIH/NIBIB, and by the Whitaker Foundation and the NSF Center for Behavioral Neuroscience. We thank Radhika Madhavan, Sheri McKinney and Eno Ekong for technical assistance.
Funders:
Funding AgencyGrant Number
NIHNS38628
NIHEB000786
Whitaker FoundationUNSPECIFIED
NSFUNSPECIFIED
Subject Keywords:Cultured neural network; spike-timing-dependent plasticity (STDP); frequency-dependent depression; multi-electrode array (MEA); spatio-temporal dynamics; tetanization; model; plasticity; cortex; bursting; population coding
Issue or Number:3
PubMed Central ID:PMC2584804
DOI:10.1385/ni:3:3:263
Record Number:CaltechAUTHORS:20200320-082655455
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200320-082655455
Official Citation:Chao, Z.C., Bakkum, D.J., Wagenaar, D.A. et al. Effects of random external background stimulation on network synaptic stability after tetanization. Neuroinform 3, 263–280 (2005). https://doi.org/10.1385/NI:3:3:263
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102015
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Mar 2020 15:44
Last Modified:16 Nov 2021 18:08

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