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Preparation of methionine-free natural leucine

Fox, S. W. (1936) Preparation of methionine-free natural leucine. Science, 84 (2172). p. 163. ISSN 0036-8075. doi:10.1126/science.84.2172.163.

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In a recent note in Science, Mueller pointed out that commercial I-leucine is contaminated with methionine. The presence of a sulfur-containing impurity was recognized by Emil Fischer in 1900. Unsuccessful attempts to purify natural I-leucine have included: the amino-acid ester method, repeated recrystallization from water, electrodialysis, precipitation of methionine as mercury complex and recrystallization from acidified butyl alcohol. Recrystallization of the formylated amino-acid has now been found, however, to yield a sulfur-free leucine without appreciable racemization.

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Additional Information:© 1936 American Association for the Advancement of Science.
Issue or Number:2172
Record Number:CaltechAUTHORS:20200323-155035268
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Official Citation:Preparation of methionine-free natural leucine. S. W. Fox. Science 14 Aug 1936: 163; doi: 10.1126/science.84.2172.163
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102066
Deposited By: Tony Diaz
Deposited On:23 Mar 2020 23:06
Last Modified:16 Nov 2021 18:08

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