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Preparation of methionine-free natural leucine

Fox, S. W. (1936) Preparation of methionine-free natural leucine. Science, 84 (2172). p. 163. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20200323-155035268

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Abstract

In a recent note in Science, Mueller pointed out that commercial I-leucine is contaminated with methionine. The presence of a sulfur-containing impurity was recognized by Emil Fischer in 1900. Unsuccessful attempts to purify natural I-leucine have included: the amino-acid ester method, repeated recrystallization from water, electrodialysis, precipitation of methionine as mercury complex and recrystallization from acidified butyl alcohol. Recrystallization of the formylated amino-acid has now been found, however, to yield a sulfur-free leucine without appreciable racemization.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1126/science.84.2172.163DOIArticle
Additional Information:© 1936 American Association for the Advancement of Science.
Issue or Number:2172
Record Number:CaltechAUTHORS:20200323-155035268
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200323-155035268
Official Citation:Preparation of methionine-free natural leucine. S. W. Fox. Science 14 Aug 1936: 163; doi: 10.1126/science.84.2172.163
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102066
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Mar 2020 23:06
Last Modified:23 Mar 2020 23:06

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