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Gene regulatory networks for development

Levine, Michael and Davidson, Eric H. (2005) Gene regulatory networks for development. Proceedings of the National Academy of Sciences of the United States of America, 102 (14). pp. 4936-4942. ISSN 0027-8424. PMCID PMC555974.

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The genomic program for development operates primarily by the regulated expression of genes encoding transcription factors and components of cell signaling pathways. This program is executed by cis-regulatory DNAs (e.g., enhancers and silencers) that control gene expression. The regulatory inputs and functional outputs of developmental control genes constitute network-like architectures. In this PNAS Special Feature are assembled papers on developmental gene regulatory networks governing the formation of various tissues and organs in nematodes, flies, sea urchins, frogs, and mammals. Here, we survey salient points of these networks, by using as reference those governing specification of the endomesoderm in sea urchin embryos and dorsal-ventral patterning in the Drosophila embryo.

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Additional Information:Copyright © 2005 by the National Academy of Sciences. Contributed by Eric H. Davidson and Michael Levine, February 1, 2005. We thank Dmitri Papatsenko for creating Fig. 2 and Angela Stathopoulos and Rob Zinzen for access to unpublished results. This work was supported by National Institutes of Health Grant HD37105.
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Subject Keywords:sea-urchin embryo, animal-vegetal axis, CNS midline cells, drosophila embryo, EGF receptor, ventral ectoderm, beta-catenin, spitz class, specification, activation
Issue or Number:14
PubMed Central ID:PMC555974
Record Number:CaltechAUTHORS:LEVpnas05
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1022
Deposited By: Tony Diaz
Deposited On:10 Jan 2006
Last Modified:02 Oct 2019 22:39

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