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Translation Speed Compensation in the Dorsal Aspect of the Medial Superior Temporal Area

Lee, Brian and Pesaran, Bijan and Andersen, Richard A. (2007) Translation Speed Compensation in the Dorsal Aspect of the Medial Superior Temporal Area. Journal of Neuroscience, 27 (10). pp. 2582-2591. ISSN 0270-6474. PMCID PMC6672509. doi:10.1523/jneurosci.3416-06.2007. https://resolver.caltech.edu/CaltechAUTHORS:20200401-073803280

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Abstract

The dorsal aspect of the medial superior temporal area (MSTd) is involved in the computation of heading direction from the focus of expansion (FOE) of the visual image. Our laboratory previously found that MSTd neurons adjust their focus tuning curves to compensate for shifts in the FOE produced by eye rotation (Bradley et al., 1996) as well as for changes in pursuit speed (Shenoy et al., 2002). The translation speed of an observer also affects the shift of the FOE. To investigate whether MSTd neurons can adjust their focus tuning curves to compensate for varying translation speeds, we recorded extracellular responses from 93 focus-tuned MSTd neurons in two rhesus monkeys (Macaca mulatta) performing pursuit eye movements across displays of varying translation speeds. We found that MSTd neurons had larger shifts in their tuning curves for slow translation speeds and smaller shifts for fast translation speeds. These shifts aligned the focus tuning curves with the true heading direction and not with the retinal position of the FOE. Because the eye was pursuing at the same rate for varying translation speeds, these results indicate that retinal cues related both to translation speed and extraretinal signals from pursuit eye movements are used by MSTd neurons to compute heading direction.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/jneurosci.3416-06.2007DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672509PubMed CentralArticle
ORCID:
AuthorORCID
Lee, Brian0000-0002-3592-8146
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2007 Society for Neuroscience. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received Aug. 8, 2006; revised Feb. 4, 2007; accepted Feb. 5, 2007. This work was supported by the National Eye Institute, J. G. Boswell Professorship, a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund, and a Howard Hughes Medical Institute Predoctoral Fellowship. We thank Kelsie Pejsa, Nicole Sammons, and Lea Martel for animal care and surgical assistance, Tessa Yao for administrative assistance, Viktor Shcherbatyuk for technical assistance, James A. Crowell for optic flow stimulus assistance, and Marina Brozovic and Boris Breznen for scientific discussions on this manuscript.
Funders:
Funding AgencyGrant Number
National Eye InstituteUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Burroughs Wellcome FundUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
NIHUNSPECIFIED
Subject Keywords:MSTd; optic flow; self-motion; heading perception; compensation; translation
Issue or Number:10
PubMed Central ID:PMC6672509
DOI:10.1523/jneurosci.3416-06.2007
Record Number:CaltechAUTHORS:20200401-073803280
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200401-073803280
Official Citation:Translation Speed Compensation in the Dorsal Aspect of the Medial Superior Temporal Area. Brian Lee, Bijan Pesaran, Richard A. Andersen. Journal of Neuroscience 7 March 2007, 27 (10) 2582-2591; DOI: 10.1523/JNEUROSCI.3416-06.2007
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102215
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 Apr 2020 15:42
Last Modified:04 Mar 2022 16:54

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