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A floating metal microelectrode array for chronic implantation

Musallam, Sam and Bak, Martin J. and Troyk, Philip R. and Andersen, Richard A. (2007) A floating metal microelectrode array for chronic implantation. Journal of Neuroscience Methods, 160 (1). pp. 122-127. ISSN 0165-0270. doi:10.1016/j.jneumeth.2006.09.005. https://resolver.caltech.edu/CaltechAUTHORS:20200401-074402581

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Abstract

Implantation of multi-electrode arrays is becoming increasingly more prevalent within the neuroscience research community and has become important for clinical applications. Many of these studies have been directed towards the development of sensory and motor prosthesis. Here, we present a multi-electrode system made from biocompatible material that is electrically and mechanically stable, and employs design features allowing flexibility in the geometric layout and length of the individual electrodes within the array. We also employ recent advances in laser machining of thin ceramic substrates, application of ultra-fine line gold conductors to ceramic, fabrication of extremely flexible cables, and fine wire management techniques associated with juxtaposing metal microelectrodes within a few hundred microns of each other in the development of a floating multi-electrode array (FMA). We implanted the FMA in rats and show that the FMA is capable of recording both spikes and local field potentials.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.jneumeth.2006.09.005DOIArticle
ORCID:
AuthorORCID
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2006 Elsevier B.V. Received 3 May 2006, Revised 25 August 2006, Accepted 1 September 2006, Available online 25 October 2006. The authors wish to thank Cevat Ustun, Eunjung Huang, Tessa Yao, Viktor Shcherbatyuk, Nicole Sammons and Kelsie Pejsa. We also thank the Defense Advanced Research Projects Agency (DARPA), The Swartz-Sloan Center for Theoretical Neurobiology, The National Institute of Health (NIH), The McKnight Foundation and the Industrial Outreach funds for the NSF Center for Neuromorphic Systems Engineering ERC at Caltech. The FMA microelectrode systems were developed in cooperation with Micro Probe, Inc. and in part through a SBIR Phase I grant to Micro Probe, Inc., number R43NS051036-01.
Funders:
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Sloan-Swartz Center for Theoretical NeurobiologyUNSPECIFIED
NIHR43NS051036-01
McKnight FoundationUNSPECIFIED
NSFUNSPECIFIED
Subject Keywords:Multi-electrode arrays; Neural prosthesis; Brain–machine interface; Rats
Issue or Number:1
DOI:10.1016/j.jneumeth.2006.09.005
Record Number:CaltechAUTHORS:20200401-074402581
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200401-074402581
Official Citation:Sam Musallam, Martin J. Bak, Philip R. Troyk, Richard A. Andersen, A floating metal microelectrode array for chronic implantation, Journal of Neuroscience Methods, Volume 160, Issue 1, 2007, Pages 122-127, ISSN 0165-0270, https://doi.org/10.1016/j.jneumeth.2006.09.005. (http://www.sciencedirect.com/science/article/pii/S016502700600450X)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102216
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 Apr 2020 15:40
Last Modified:16 Nov 2021 18:09

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