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Enhancing fMRI contrast in awake-behaving primates using intravascular magnetite dextran nanopartieles

Dubowitz, David J. and Bernheim, Kyle A. and Chen, Dar-Yeong and Bradley, William G., Jr. and Andersen, Richard A. (2001) Enhancing fMRI contrast in awake-behaving primates using intravascular magnetite dextran nanopartieles. Neuroreport, 12 (11). pp. 2335-2340. ISSN 0959-4965. doi:10.1097/00001756-200108080-00011.

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Functional MRI in awake-behaving primates is an emerging tool for bridging the gap between human fMRI and neurophysiology information from nonhuman primates. We report the use of magnetite dextran nanoparticles (Feridex) as a blood-pool agent to enhance fMRI contrast-to-noise (CNR) in primate FMRI. The intravascular half-life of the magnetite dextran was long compared to lanthanide chelates (T_(1/2) = 198 min) with shortened T₂ relaxation observed in blood and cerebral cortex. Greater than 3-fold enhancement in the percentage MR signal change was observed using nanoparticles (13%) compared with conventional BOLD fMRI (4%). The calculated regional cerebral blood volume in macaque primary visual cortex increased 32% with photic stimulation. The increased CNR allows greater flexibility in the design of awake-behaving primate fMRI studies with the potential for improvements in resolution and significantly shortened imaging times.

Item Type:Article
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Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2001 Lippincott Williams & Wilkins, Inc. Received 11 April 2001; accepted 25 May 2001. We gratefully acknowledge J. Michael Tyszka for enlightened discussion and Betty Gillikin for help with animal handling and health care. This work was funded in part by grants from National Institutes of Health (GM08042 and EY07492) and a James G. Boswell Professorship (R.A.A.).
Funding AgencyGrant Number
James G. Boswell FoundationUNSPECIFIED
Subject Keywords:Cerebral blood volume, Feridex, fMRI, Functional activation, Magnetite, Rhesus macaque monkey, Visual cortex
Issue or Number:11
Record Number:CaltechAUTHORS:20200401-102801873
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102235
Deposited By: Tony Diaz
Deposited On:01 Apr 2020 17:48
Last Modified:16 Nov 2021 18:10

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