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Direct comparison of visual cortex activation in human and non-human primates using functional magnetic resonance imaging

Dubowitz, David J. and Chen, Dar-Yeong and Atkinson, Dennis J. and Scadeng, Miriam and Martinez, Antigona and Andersen, Michael B. and Andersen, Richard A. and Bradley, William G., Jr. (2001) Direct comparison of visual cortex activation in human and non-human primates using functional magnetic resonance imaging. Journal of Neuroscience Methods, 107 (1-2). pp. 71-80. ISSN 0165-0270. doi:10.1016/s0165-0270(01)00353-3. https://resolver.caltech.edu/CaltechAUTHORS:20200401-122353403

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Abstract

We report a technique for functional magnetic resonance imaging (fMRI) in an awake, co-operative, rhesus macaque (Macaca mulatta) in a conventional 1.5T clinical MR scanner, thus accomplishing the first direct comparison of activation in visual cortex between humans and non-human primates with fMRI. Activation was seen in multiple areas of striate and extra-striate visual cortex and in areas for motion, object and face recognition in the monkey and in homologous visual areas in a human volunteer. This article describes T₁, T₂ and T₂* values for macaque cortex, suitable MR imaging sequences, a training schedule, stimulus delivery apparatus and restraining hardware for monkey fMRI using a conventional 19 cm knee coil. Much of our understanding of the functional organization of the primate brain comes from physiological studies in monkeys. Direct comparison between species using fMRI such as those described here will help us to relate the wealth of existing knowledge on the functional organization of the non-human primate brain to human fMRI.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/s0165-0270(01)00353-3DOIArticle
ORCID:
AuthorORCID
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2001 Elsevier Science B.V. Received 7 August 2000, Revised 6 March 2001, Accepted 6 March 2001, Available online 30 May 2001. We thank Chris Headrick for the illustration (Fig. 1), Betty Gillikin for animal care assistance and Marty Sereno for enlightening discussion and assistance with data interpretation. This work is supported by grants from the Pasadena Neurosciences Fellowship of Huntington Medical Research Institutes (DJD) and the National Eye Institute (RAA).
Funders:
Funding AgencyGrant Number
Huntington Medical Research Institute (HMRI)UNSPECIFIED
National Eye InstituteUNSPECIFIED
NIHUNSPECIFIED
Subject Keywords:MRI; fMRI; Functional activation; Human; Rhesus macaque monkey; Visual cortex; T1; T2; T2*
Issue or Number:1-2
DOI:10.1016/s0165-0270(01)00353-3
Record Number:CaltechAUTHORS:20200401-122353403
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200401-122353403
Official Citation:David J Dubowitz, Dar-Yeong Chen, Dennis J Atkinson, Miriam Scadeng, Antigona Martinez, Michael B Andersen, Richard A Andersen, William G Bradley, Direct comparison of visual cortex activation in human and non-human primates using functional magnetic resonance imaging, Journal of Neuroscience Methods, Volume 107, Issues 1–2, 2001, Pages 71-80, ISSN 0165-0270, https://doi.org/10.1016/S0165-0270(01)00353-3. (http://www.sciencedirect.com/science/article/pii/S0165027001003533)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102239
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 Apr 2020 22:08
Last Modified:16 Nov 2021 18:10

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