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Functional magnetic resonance imaging in macaque cortex

Dubowitz, David J. and Chen, Dar-Yeong and Atkinson, Dennis J. and Grieve, Kenneth L. and Gillikin, Betty and Bradley, William G., Jr. and Andersen, Richard A. (1998) Functional magnetic resonance imaging in macaque cortex. Neuroreport, 9 (10). pp. 2213-2218. ISSN 0959-4965. doi:10.1097/00001756-199807130-00012.

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The ability to use fMRI in a monkey model would bridge the gap between the fMRI demonstration of cerebral activation in humans and the cumulative wealth of monkey data on the functional organization of the brain from single electrode mapping, radioisotope and histology studies. We report a new technique for fMRI in an awake co-operative rhesus macaque (Macaca mulatta) in a conventional clinical 1.5T MR scanner and present the first fMRI images from a macaque. Good resolution, signal-to-noise ratio and BOLD response (2.6–4.6%) have been achieved using the manufacturer's standard volume knee coil. T1 values of macaque gray and white matter (1490 ms, 1010 ms respectively) are higher than human brain, whereas T2 values are lower (55 ms, 48 ms respectively). An MR-compatible design for restraining the monkey is also described, along with a suitable EPI sequence for BOLD images, optimized for monkey T2, with voxel sizes from 29 to 61 μl, and MPRAGE sequence for anatomical studies with 0.8 mm isotropic resolution, optimized for monkey T1.

Item Type:Article
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Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 1998 Lippincott-Raven Publishers.
Subject Keywords:fMRI, Functional activation, Rhesus macaque monkey, Visual cortex
Issue or Number:10
Record Number:CaltechAUTHORS:20200402-074422922
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102256
Deposited By: Tony Diaz
Deposited On:02 Apr 2020 15:02
Last Modified:16 Nov 2021 18:10

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