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A Multi-Dimensional Analysis of a Novel Approach for Wireless Stimulation

Abiri, Parinaz and Yousefi, Alireza and Abiri, Arash and Gudapati, Varun and Ding, Yichen and Nguyen, Kim-Lien and Abiri, Ahmad and Markovic, Dejan and Tai, Yu-Chong and Hsiai, Tzung K. (2020) A Multi-Dimensional Analysis of a Novel Approach for Wireless Stimulation. IEEE Transactions on Biomedical Engineering . ISSN 0018-9294. (In Press)

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The elimination of integrated batteries in biomedical implants holds great promise for improving health outcomes in patients with implantable devices. However, despite extensive research in wireless power transfer, achieving efficient power transfer and effective operational range have remained a hindering challenge within anatomical constraints. Objective: We hereby demonstrate an intravascular wireless and batteryless microscale stimulator, designed for (1) low power dissipation via intermittent transmission and (2) reduced fixation mechanical burden via deployment to the anterior cardiac vein (ACV, ~3.8 mm in diameter). Methods: We introduced a unique coil design circumferentially confined to a 3 mm diameter hollow-cylinder that was driven by a novel transmitter-based control architecture with improved power efficiency. Results: We examined wireless capacity using heterogenous bovine tissue, demonstrating >5 V stimulation threshold with up to 20 mm transmitter-receiver displacement and 20 degrees of misalignment. Feasibility for human use was validated using Finite Element Method (FEM) simulation of the cardiac cycle, guided by pacer phantom-integrated Magnetic Resonance Images (MRI). Conclusion: This system design thus enabled sufficient wireless power transfer in the face of extensive stimulator miniaturization. Significance: Our successful feasibility studies demonstrated the capacity for minimally invasive deployment and low-risk fixation.

Item Type:Article
Related URLs:
URLURL TypeDescription
Ding, Yichen0000-0002-6242-3506
Tai, Yu-Chong0000-0001-8529-106X
Hsiai, Tzung K.0000-0003-1734-0792
Additional Information:© 2020 IEEE. Manuscript received June 7, 2019. This work was supported by National Institute of Health HL118650 (TKH), HL129727 (TKH), HL111437 (TKH), BX004356 (TKH), EB0220002 (TKH), and NIH NIGMS training grant GM008042 (PA) and UCLA David Geffen Scholarship (PA).
Funding AgencyGrant Number
NIH Predoctoral FellowshipGM008042
Subject Keywords:wireless medical devices, wireless pacemaker, inductive power transfer, implantable medical devices, implantable cardiovascular devices
Record Number:CaltechAUTHORS:20200403-142831278
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102333
Deposited By: Tony Diaz
Deposited On:03 Apr 2020 21:51
Last Modified:03 Apr 2020 21:51

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