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Common Fronto-temporal Effective Connectivity in Humans and Monkeys

Rocchi, Francesca and Oya, Hiroyuki and Balezeau, Fabien and Billig, Alexander J. and Kocsis, Zsuzsanna and Jenison, Rick and Nourski, Kirill V. and Kovach, Christopher K. and Steinschneider, Mitchell and Kikuchi, Yukiko and Rhone, Ariane E. and Dlouhy, Brian J. and Kawasaki, Hiroto and Adolphs, Ralph and Greenlee, Jeremy D. W. and Griffiths, Timothy D. and Howard, Matthew A. and Petkov, Christopher I. (2020) Common Fronto-temporal Effective Connectivity in Humans and Monkeys. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20200406-083835864

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Abstract

Cognitive pathways supporting human language and declarative memory are thought to have uniquely evolutionarily differentiated in our species. However, cross-species comparisons are missing on site-specific effective connectivity between regions important for cognition. We harnessed a new approach using functional imaging to visualize the impact of direct electrical brain stimulation in human neurosurgery patients. Applying the same approach with macaque monkeys, we found remarkably comparable patterns of effective connectivity between auditory cortex and ventro-lateral prefrontal cortex (vlPFC) and parahippocampal cortex in both species. Moreover, in humans electrical tractography revealed rapid evoked potentials in vlPFC from stimulating auditory cortex and speech sounds drove vlPFC, consistent with prior evidence in monkeys of direct projections from auditory cortex to vocalization responsive regions in vlPFC. The results identify a common effective connectivity signature that from auditory cortex is equally direct to vlPFC and indirect to the hippocampus (via parahippocampal cortex) in human and nonhuman primates.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/2020.04.03.024042DOIDiscussion Paper
ORCID:
AuthorORCID
Rocchi, Francesca0000-0003-3300-4633
Oya, Hiroyuki0000-0002-1733-5478
Balezeau, Fabien0000-0003-2354-6949
Billig, Alexander J.0000-0002-4531-8616
Kocsis, Zsuzsanna0000-0003-2203-2786
Nourski, Kirill V.0000-0002-7152-8473
Kovach, Christopher K.0000-0002-0117-151X
Kikuchi, Yukiko0000-0002-0365-0397
Rhone, Ariane E.0000-0002-5699-8733
Dlouhy, Brian J.0000-0001-6724-688X
Kawasaki, Hiroto0000-0002-7688-9171
Adolphs, Ralph0000-0002-8053-9692
Greenlee, Jeremy D. W.0000-0002-8481-8517
Griffiths, Timothy D.0000-0001-8066-4381
Howard, Matthew A.0000-0003-3935-8889
Petkov, Christopher I.0000-0002-4932-7907
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. Posted April 05, 2020. Supported by Wellcome Trust (CIP: WT092606AIA; TDG: WT091681MA), Biotechnology and Biological Sciences Research Council UK (CIP: BB/J009849/1), National Institutes of Health USA (MAH: R01-DC04290; JDWG: R01-DC015260; RA and MAH: U01-NS103780) and European Research Council (CIP: ERC CoG, MECHIDENT). We thank Lauren Dean and Jennifer Nacef for assistance with the macaque data collection, and Haiming Chen, Phil Gander and Beau Snoad for assistance with the human data collection. Author Contributions: Conceptualization: CIP, MAH, TDG. Investigation: FR, HO, FB, AER, KVN, MS, YK, HK, CIP. Formal Analysis: FR, HO, ZK, RJ, CIP. Resources: FB, AB, CKK, KVN, YK, BJD, HK, RA, JDWG, TDG, MAH, CIP. Writing – Original Draft: FR, HO, CIP. Writing – Review & Editing: FR, HO, FB, AB, ZK, RJ, KVN, YK, BJD, RA, JDWG, TDG, MAH, CIP. Supervision: MAH & CIP. Project administration: HO, FR, FB, AER, KVN, MAH, CIP. Funding acquisition: RA, JDWG, TDG, MAH, CIP. The authors declare no competing or financial interests.
Funders:
Funding AgencyGrant Number
Wellcome TrustWT092606AIA
Wellcome TrustWT091681MA
Biotechnology and Biological Sciences Research Council (BBSRC)BB/J009849/1
NIHR01-DC04290
NIHR01-DC015260
NIHU01-NS103780
European Research Council (ERC)MECHIDENT
Subject Keywords:Language, cognition, declarative memory, evolution, neurophysiology, neuroimaging
Record Number:CaltechAUTHORS:20200406-083835864
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200406-083835864
Official Citation:Common Fronto-temporal Effective Connectivity in Humans and Monkeys. Francesca Rocchi, Hiroyuki Oya, Fabien Balezeau, Alexander J Billig, Zsuzsanna Kocsis, Rick Jenison, Kirill V Nourski, Christopher K Kovach, Mitchell Steinschneider, Yukiko Kikuchi, Ariane E Rhone, Brian J Dlouhy, Hiroto Kawasaki, Ralph Adolphs, Jeremy D W Greenlee, Timothy D Griffiths, Matthew A Howard III, Christopher I Petkov. bioRxiv 2020.04.03.024042; doi: https://doi.org/10.1101/2020.04.03.024042
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102340
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Apr 2020 18:48
Last Modified:06 Apr 2020 18:48

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