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Decrease in ACE2 mRNA expression in aged mouse lung

Booeshaghi, A. Sina and Pachter, Lior (2020) Decrease in ACE2 mRNA expression in aged mouse lung. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20200406-101324270

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Abstract

Angiotensin-converting enzyme 2 (ACE2) has been identified as a critical receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This has led to extensive speculation on the role of ACE2 in disease severity, and in particular, whether variation in its expression can explain higher mortality in older individuals. We examine this question in mouse lung and show that 24-month old mice have significantly reduced ACE2 mRNA expression relative to 3-month old mice. The differences appear to be localized to ciliated cells.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/2020.04.02.021451DOIDiscussion Paper
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE124872Related ItemData
https://github.com/pachterlab/BP_2020Related ItemData/Code
ORCID:
AuthorORCID
Booeshaghi, A. Sina0000-0002-6442-4502
Pachter, Lior0000-0002-9164-6231
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. Posted April 05, 2020. Data availability: Raw FASTQ files can be obtained from GSE124872.
Record Number:CaltechAUTHORS:20200406-101324270
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200406-101324270
Official Citation:Decrease in ACE2 mRNA expression in aged mouse lung. A. Sina Booeshaghi, Lior Pachter. bioRxiv 2020.04.02.021451; doi: https://doi.org/10.1101/2020.04.02.021451
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102345
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Apr 2020 18:33
Last Modified:06 Apr 2020 18:33

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