Decrease in ACE2 mRNA expression in aged mouse lung

Booeshaghi, A. Sina and Pachter, Lior (2020) Decrease in ACE2 mRNA expression in aged mouse lung. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20200406-101324270

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Abstract

Angiotensin-converting enzyme 2 (ACE2) has been identified as a critical receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This has led to extensive speculation on the role of ACE2 in disease severity, and in particular, whether variation in its expression can explain higher mortality in older individuals. We examine this question in mouse lung and show that 24-month old mice have significantly reduced ACE2 mRNA expression relative to 3-month old mice. The differences appear to be localized to ciliated cells.

Item Type:

Report or Paper (Discussion Paper)

Related URLs:

URL	URL Type	Description
https://doi.org/10.1101/2020.04.02.021451	DOI	Discussion Paper
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE124872	Related Item	Data
https://github.com/pachterlab/BP_2020	Related Item	Data/Code

ORCID:

Author	ORCID
Booeshaghi, A. Sina	0000-0002-6442-4502
Pachter, Lior	0000-0002-9164-6231

Additional Information:

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. Posted April 05, 2020. Data availability: Raw FASTQ files can be obtained from GSE124872.

Group:

COVID-19

DOI:

10.1101/2020.04.02.021451

Record Number:

CaltechAUTHORS:20200406-101324270

Persistent URL:

https://resolver.caltech.edu/CaltechAUTHORS:20200406-101324270

Official Citation:

Decrease in ACE2 mRNA expression in aged mouse lung. A. Sina Booeshaghi, Lior Pachter. bioRxiv 2020.04.02.021451; doi: https://doi.org/10.1101/2020.04.02.021451

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No commercial reproduction, distribution, display or performance rights in this work are provided.

ID Code:

102345

Collection:

CaltechAUTHORS

Deposited By:

Tony Diaz

Deposited On:

06 Apr 2020 18:33

Last Modified:

16 Nov 2021 18:11

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