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Online detection and sorting of extracellularly recorded action potentials in human medial temporal lobe recordings, in vivo

Rutishauser, Ueli and Schuman, Erin M. and Mamelak, Adam N. (2006) Online detection and sorting of extracellularly recorded action potentials in human medial temporal lobe recordings, in vivo. Journal of Neuroscience Methods, 154 (1-2). pp. 204-224. ISSN 0165-0270. https://resolver.caltech.edu/CaltechAUTHORS:20200406-135652462

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Abstract

Understanding the function of complex cortical circuits requires the simultaneous recording of action potentials from many neurons in awake and behaving animals. Practically, this can be achieved by extracellularly recording from multiple brain sites using single wire electrodes. However, in densely packed neural structures such as the human hippocampus, a single electrode can record the activity of multiple neurons. Thus, analytic techniques that differentiate action potentials of different neurons are required. Offline spike sorting approaches are currently used to detect and sort action potentials after finishing the experiment. Because the opportunities to record from the human brain are relatively rare, it is desirable to analyze large numbers of simultaneous recordings quickly using online sorting and detection algorithms. In this way, the experiment can be optimized for the particular response properties of the recorded neurons. Here we present and evaluate a method that is capable of detecting and sorting extracellular single-wire recordings in realtime. We demonstrate the utility of the method by applying it to an extensive data set we acquired from chronically implanted depth electrodes in the hippocampus of human epilepsy patients. This dataset is particularly challenging because it was recorded in a noisy clinical environment. This method will allow the development of “closed-loop” experiments, which immediately adapt the experimental stimuli and/or tasks to the neural response observed.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.jneumeth.2005.12.033DOIArticle
https://arxiv.org/abs/q-bio/0604033arXivDiscussion Paper
ORCID:
AuthorORCID
Rutishauser, Ueli0000-0002-9207-7069
Schuman, Erin M.0000-0002-7053-1005
Mamelak, Adam N.0000-0002-4245-6431
Additional Information:© 2006 Elsevier B.V. Received 11 May 2005, Revised 10 December 2005, Accepted 22 December 2005, Available online 20 February 2006. Our implementation as well as the simulated datasets are available at http://emslab.caltech.edu/software/spikesorter.html. This research was supported by the Sloan-Swartz Center for theoretical neurobiology (U.R.), the Howard Hughes Medical Institute and the Gimbel Discovery Fund.
Funders:
Funding AgencyGrant Number
Sloan-Swartz Center for Theoretical NeurobiologyUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Gimbel Discovery FundUNSPECIFIED
Subject Keywords:Online sorting; Human hippocampus; Extracellular single-unit recordings
Issue or Number:1-2
Record Number:CaltechAUTHORS:20200406-135652462
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200406-135652462
Official Citation:Ueli Rutishauser, Erin M. Schuman, Adam N. Mamelak, Online detection and sorting of extracellularly recorded action potentials in human medial temporal lobe recordings, in vivo, Journal of Neuroscience Methods, Volume 154, Issues 1–2, 2006, Pages 204-224, ISSN 0165-0270, https://doi.org/10.1016/j.jneumeth.2005.12.033. (http://www.sciencedirect.com/science/article/pii/S0165027006000033)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102356
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Apr 2020 21:25
Last Modified:06 Apr 2020 21:25

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