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Lysine-specific demethylase 1 as a potential therapeutic target

Stavropoulos, Pete and Hoelz, André (2007) Lysine-specific demethylase 1 as a potential therapeutic target. Expert Opinion on Therapeutic Targets, 11 (6). pp. 809-820. ISSN 1472-8222. doi:10.1517/14728222.11.6.809. https://resolver.caltech.edu/CaltechAUTHORS:20200407-081141568

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Abstract

Chromatin is a highly dynamic structure that undergoes a variety of chemical modifications. These modifications mediate alterations of the chromatin architecture, generate binding platforms that are recognized by other proteins, and are important elements of epigenetic gene regulation. An array of antagonizing histone modifying enzymes that catalyze the attachment and removal of a number of chemical groups has been described and their biologic role has been an intense area of research. With the recent discovery of the first histone demethylase, lysine-specific demethylase-1, a dynamic view of histone methylation was born. As a deeper understanding of their involvement in transcriptional regulation is gained, histone demethylases are becoming increasingly interesting targets for drug development.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1517/14728222.11.6.809DOIArticle
ORCID:
AuthorORCID
Hoelz, André0000-0003-1726-0127
Additional Information:© 2007 Informa Healthcare. Published online: 15 May 2007. The authors thank Günter Blobel for continuing support and critical reading of the manuscript, Stephanie Etherton for help with editing of the manuscript and Alina Patke for insightful discussions. André Hoelz was supported by a grant from the Leukemia and Lymphoma Society.
Funders:
Funding AgencyGrant Number
Leukemia and Lymphoma SocietyUNSPECIFIED
Subject Keywords:drug development, histone demethylase, LSD1, structure
Issue or Number:6
DOI:10.1517/14728222.11.6.809
Record Number:CaltechAUTHORS:20200407-081141568
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200407-081141568
Official Citation:Pete Stavropoulos & André Hoelz (2007). Lysine-specific demethylase 1 as a potential therapeutic target, Expert Opinion on Therapeutic Targets, 11:6, 809-820, DOI: 10.1517/14728222.11.6.809
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102369
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 Apr 2020 15:45
Last Modified:16 Nov 2021 18:11

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