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Comparative analysis of human and mouse development: From zygote to pre-gastrulation

Molè, Matteo A. and Weberling, Antonia and Zernicka-Goetz, Magdalena (2020) Comparative analysis of human and mouse development: From zygote to pre-gastrulation. In: Gastrulation: From Embryonic Pattern to Form. Current Topics in Developmental Biology. No.136. Elsevier , Cambridge, MA, pp. 113-138. ISBN 9780128127988.

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Development of the mammalian embryo begins with formation of the totipotent zygote during fertilization. This initial cell is able to give rise to every embryonic tissue of the developing organism as well as all extra-embryonic lineages, such as the placenta and the yolk sac, which are essential for the initial patterning and support growth of the fetus until birth. As the embryo transits from pre- to post-implantation, major structural and transcriptional changes occur within the embryonic lineage to set up the basis for the subsequent phase of gastrulation. Fine-tuned coordination of cell division, morphogenesis and differentiation is essential to ultimately promote assembly of the future fetus. Here, we review the current knowledge of mammalian development of both mouse and human focusing on morphogenetic processes leading to the onset of gastrulation, when the embryonic anterior-posterior axis becomes established and the three germ layers start to be specified.

Item Type:Book Section
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Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2020 Elsevier. Available online 26 December 2019.
Subject Keywords:Human embryo; Pre-implantation; Blastocyst; Implantation; Trophectoderm; Pro-amniotic cavity; Post-implantation; Epiblast; Anterior-posterior axis; Gastrulation
Series Name:Current Topics in Developmental Biology
Issue or Number:136
Record Number:CaltechAUTHORS:20200409-115737860
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Official Citation:Matteo A. Molè, Antonia Weberling, Magdalena Zernicka-Goetz, Chapter Four - Comparative analysis of human and mouse development: From zygote to pre-gastrulation, Editor(s): Lilianna Solnica-Krezel, Current Topics in Developmental Biology, Academic Press, Volume 136, 2020, Pages 113-138, ISSN 0070-2153, ISBN 9780128127988,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102439
Deposited By: George Porter
Deposited On:09 Apr 2020 20:49
Last Modified:16 Nov 2021 18:12

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