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Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives

Zhu, Meng and Zernicka-Goetz, Magdalena (2020) Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives. Current Opinion in Cell Biology, 62 . pp. 144-149. ISSN 0955-0674. doi:10.1016/

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Cell polarization is critical for lineage segregation and morphogenesis during mammalian embryogenesis. However, the processes and mechanisms that establish cell polarity in the mammalian embryo are not well understood. Recent studies suggest that unique regulatory mechanisms are deployed by the mouse embryo to establish cell polarization. In this review, we discuss the current understanding of cell polarity establishment, focusing on the formation of the apical domain in the mouse embryo. We will also discuss outstanding questions and possible directions for future study.

Item Type:Article
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URLURL TypeDescription
Zhu, Meng0000-0001-6157-8840
Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2019 Elsevier. Available online 21 December 2019. This review comes from a themed issue on Cell architecture; Edited by Sandrine Etienne-Manneville and Robert Arkowitz. We thank Christos Kyprianou and Hannah Mudge for their feedback on the manuscript. M.Z.G receives funding from Wellcome Trust, ERC, and Leverhulme Trust. M.Z is funded by Leverhulme Trust. Conflict of interest statement: Nothing declared.
Funding AgencyGrant Number
Leverhulme TrustUNSPECIFIED
European Research Council (ERC)UNSPECIFIED
Subject Keywords:Mouse embryo; De novo cell polarity establishment; Apical domain; Par complex; Actomyosin; Protein clustering
Record Number:CaltechAUTHORS:20200409-115737960
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Official Citation:Meng Zhu, Magdalena Zernicka-Goetz, Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives, Current Opinion in Cell Biology, Volume 62, 2020, Pages 144-149, ISSN 0955-0674,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102440
Deposited By: George Porter
Deposited On:09 Apr 2020 20:51
Last Modified:16 Nov 2021 18:12

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