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Self-organization of stem cells into embryos: A window on early mammalian development

Shahbazi, Marta N. and Siggia, Eric D. and Zernicka-Goetz, Magdalena (2019) Self-organization of stem cells into embryos: A window on early mammalian development. Science, 364 (6444). pp. 948-951. ISSN 0036-8075. doi:10.1126/science.aax0164. https://resolver.caltech.edu/CaltechAUTHORS:20200409-115738157

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Abstract

Embryonic development is orchestrated by robust and complex regulatory mechanisms acting at different scales of organization. In vivo studies are particularly challenging for mammals after implantation, owing to the small size and inaccessibility of the embryo. The generation of stem cell models of the embryo represents a powerful system with which to dissect this complexity. Control of geometry, modulation of the physical environment, and priming with chemical signals reveal the intrinsic capacity of embryonic stem cells to make patterns. Adding the stem cells for the extraembryonic lineages generates three-dimensional models that are more autonomous from the environment and recapitulate many features of the pre- and postimplantation mouse embryo, including gastrulation. Here, we review the principles of self-organization and how they set cells in motion to create an embryo.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1126/science.aax0164DOIArticle
ORCID:
AuthorORCID
Shahbazi, Marta N.0000-0002-1599-5747
Siggia, Eric D.0000-0001-7482-1854
Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuse. This is an article distributed under the terms of the Science Journals Default License. We are grateful to N. Rivron, B. Sozen, D. Turner, A. Martinez-Arias, J. Fu, M. Simunovic, A. Yoney, R. Nusse, D. ten Berge, and W. Koole for providing images for Fig. 2. M.N.S received funding from an Early Career Leverhulme Trust fellowship and an Advanced EMBO fellowship. Work in the laboratory of M.Z-G. is funded by the Wellcome Trust (207415/Z/17/Z) and the European Research Council (ERC grant 669198). Work of E.D.S. is funded by NIH grant GM101653. Author contributions: M.N.S., E.D.S., and M.Z.-G. conceptualized, wrote, and edited the manuscript. Competing interests: E.D.S. is a cofounder of Rumi Scientific.
Funders:
Funding AgencyGrant Number
Leverhulme TrustUNSPECIFIED
European Molecular Biology Organization (EMBO)UNSPECIFIED
Wellcome Trust207415/Z/17/Z
European Research Council (ERC)669198
NIHGM101653
Issue or Number:6444
DOI:10.1126/science.aax0164
Record Number:CaltechAUTHORS:20200409-115738157
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200409-115738157
Official Citation:Self-organization of stem cells into embryos: A window on early mammalian development BY MARTA N. SHAHBAZI, ERIC D. SIGGIA, MAGDALENA ZERNICKA-GOETZ Science 07 Jun 2019: Vol. 364, Issue 6444, pp. 948-951 DOI: 10.1126/science.aax0164
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102442
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:09 Apr 2020 22:37
Last Modified:16 Nov 2021 18:12

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