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De novo neurogenesis in the post-embryonic zebrafish enteric nervous system from Schwann cell precursors rather than resident cell types

El-Nachef, Wael and Bronner, Marianne (2020) De novo neurogenesis in the post-embryonic zebrafish enteric nervous system from Schwann cell precursors rather than resident cell types. Neurogastroenterology and Motility, 32 (S1). Art. No. 29. ISSN 1350-1925. https://resolver.caltech.edu/CaltechAUTHORS:20200409-140201559

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Abstract

The enteric nervous system (ENS) is essential for normal gastrointestinal motility, and defects in its function define several difficult to treat conditions. While the developmental origin of the ENS from neural crest cells is well understood, there is conflicting evidence regarding postnatal enteric neurogenesis and neuronal homeostasis. Using zebrafish as a model due to its simplified ENS which is amenable to live-imaging, we sought to explore the origin of enteric neurons that arise in post-embryonic life in both normal development and upon injury, and tested effects of the 5-HT₄ receptor agonist, prucalopride, in this process.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1111/nmo.13817DOIArticle
https://resolver.caltech.edu/CaltechAUTHORS:20200603-132940388Related ItemJournal Article
ORCID:
AuthorORCID
Bronner, Marianne0000-0003-4274-1862
Additional Information:© 2020 The Authors. Neurogastroenterology & Motility © 2020 John Wiley & Sons Ltd. Issue Online: 22 March 2020; Version of Record online: 22 March 2020.
Issue or Number:S1
Record Number:CaltechAUTHORS:20200409-140201559
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200409-140201559
Official Citation:(2020), Poster Presentations. Neurogastroenterology & Motility, 32: e13817. doi:10.1111/nmo.13817
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102461
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Apr 2020 21:13
Last Modified:23 Jun 2020 21:04

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