CaltechAUTHORS
  A Caltech Library Service

Prenatal and postnatal exposure risk assessment of chlorinated paraffins in mothers and neonates: Occurrence, congener profile, and transfer behavior

Liu, Yingxue and Aamir, Muhammad and Li, Mengying and Liu, Kai and Hu, Yuhong and Liu, Nian and Xu, Yunfeng and Du, Jiyu and Xu, Jianrong and Liu, Weiping (2020) Prenatal and postnatal exposure risk assessment of chlorinated paraffins in mothers and neonates: Occurrence, congener profile, and transfer behavior. Journal of Hazardous Materials, 395 . Art. No. 122660. ISSN 0304-3894. https://resolver.caltech.edu/CaltechAUTHORS:20200414-134212132

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20200414-134212132

Abstract

Gestation and lactation are very sensitive and vulnerable stages for human growth and development. During these two periods, short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs) can be transported to neonates via transplacental and breastfeeding transfers, and eventually posing potential adverse effects to neonates. Up to date, no simultaneous investigation of prenatal and postnatal exposure of CPs is reported. To bridge this knowledge gap, we have analyzed SCCPs and MCCPs in 20 complete sets of maternal serum, umbilical cord serum, placenta, and breast milk. The levels of both ∑SCCP and ∑MCCP followed the order of maternal serum > breast milk > cord serum > placenta. The breastfeeding transfer ratios (R_(BM), ≈ 1.0) of CPs were greater than the corresponding transplacental transfer ratios (R_(CM), < 1.0), demonstrating the higher transport of CPs during the lactation period. The placental retention/or accumulation ratios (R_(PM)) showed that CPs were effectively retained by the placental barrier. Furthermore, the total exposure amounts of SCCPs and MCCPs during the lactation period was > 100 times higher than the gestation exposure amounts. This study helps to better understand the prenatal and postnatal exposure of CPs and provides a solid basis for accurate human health risk assessment of CPs.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.jhazmat.2020.122660DOIArticle
ORCID:
AuthorORCID
Aamir, Muhammad0000-0003-0579-5757
Liu, Kai0000-0002-2109-8196
Liu, Weiping0000-0002-1173-892X
Additional Information:© 2020 Elsevier B.V. Received 27 February 2020, Revised 3 April 2020, Accepted 3 April 2020, Available online 13 April 2020.
Funders:
Funding AgencyGrant Number
National Natural Science Foundation of China21427815
National Natural Science Foundation of China21621005
Subject Keywords:SCCPs; MCCPs; Transplacental transfer; Breastfeeding transfer; Neonatal exposure
Record Number:CaltechAUTHORS:20200414-134212132
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200414-134212132
Official Citation:Yingxue Liu, Muhammad Aamir, Mengying Li, Kai Liu, Yuhong Hu, Nian Liu, Yunfeng Xu, Jiyu Du, Jianrong Xu, Weiping Liu, Prenatal and postnatal exposure risk assessment of chlorinated paraffins in mothers and neonates: Occurrence, congener profile, and transfer behavior, Journal of Hazardous Materials, Volume 395, 2020, 122660, ISSN 0304-3894, https://doi.org/10.1016/j.jhazmat.2020.122660. (http://www.sciencedirect.com/science/article/pii/S030438942030649X)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102534
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 Apr 2020 20:54
Last Modified:29 Apr 2020 18:39

Repository Staff Only: item control page