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Growth regulation by oncogenes — new insights from model organisms

Prober, David A. and Edgar, Bruce A. (2001) Growth regulation by oncogenes — new insights from model organisms. Current Opinion in Genetics and Development, 11 (1). pp. 19-26. ISSN 0959-437X. doi:10.1016/s0959-437x(00)00151-9.

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A great deal of work has focused on how oncogenes regulate the cell cycle during normal development and in cancer, yet their roles in regulating cell growth have been largely unexplored. Recent work in several model organisms has demonstrated that homologs of several oncogenes regulate cell growth and has suggested that some of the effects of oncogenes on the cell cycle may be a result of growth promotion. These studies have also suggested how growth and cell-cycle progression may be coupled.

Item Type:Article
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Prober, David A.0000-0002-7371-4675
Additional Information:© 2001 Elsevier Science Ltd. Available online 9 January 2001. We thank Ed Giniger, Sally Leevers, Piotr Sicinski, and George Thomas for helpful discussions and comments on the manuscript.
Subject Keywords:Oncogene; Growth; Cell cycle; Cell proliferation; Model organism; Development
Issue or Number:1
Record Number:CaltechAUTHORS:20200415-132631728
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Official Citation:David A Prober, Bruce A Edgar, Growth regulation by oncogenes — new insights from model organisms, Current Opinion in Genetics & Development, Volume 11, Issue 1, 2001, Pages 19-26, ISSN 0959-437X, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102564
Deposited By: Tony Diaz
Deposited On:15 Apr 2020 20:56
Last Modified:16 Nov 2021 18:13

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