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Drosophila myc Regulates Cellular Growth during Development

Johnston, Laura A. and Prober, David A. and Edgar, Bruce A. and Eisenman, Robert N. and Gallant, Peter (1999) Drosophila myc Regulates Cellular Growth during Development. Cell, 98 (6). pp. 779-790. ISSN 0092-8674. doi:10.1016/s0092-8674(00)81512-3.

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Transcription factors of the Myc proto-oncogene family promote cell division, but how they do this is poorly understood. Here we address the functions of Drosophila Myc (dMyc) during development. Using mosaic analysis in the fly wing, we show that loss of dMyc retards cellular growth (accumulation of cell mass) and reduces cell size, whereas dMyc overproduction increases growth rates and cell size. dMyc-induced growth promotes G1/S progression but fails to accelerate cell division because G2/M progression is independently controlled by Cdc25/String. We also show that the secreted signal Wingless patterns growth in the wing primordium by modulating dMyc expression. Our results indicate that dMyc links patterning signals to cell division by regulating primary targets involved in cellular growth and metabolism.

Item Type:Article
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Prober, David A.0000-0002-7371-4675
Additional Information:© 1999 Cell Press. Received 9 June 1999, Revised 11 August 1999. We thank members of the Edgar and Eisenman labs for discussions during the course of the work; S. Parkhurst for advice and resources; A. de la Cruz, P. F. Cheng, A. Berger, L. Caldwell, and K. Seidel for technical assistance; and M. Groudine, E. Hafen, T. Neufeld, and J. Roberts for comments on the manuscript. Work in the Edgar lab is supported by the National Institutes of Health, and support for the Eisenman lab comes from the National Cancer Institute. L. A. J. was supported by NIH funding to G. Schubiger and P. G. by the Swiss National Science Foundation. B. A. E. is a Rita Allen Scholar, and R. N. E. is a Research Professor of the American Cancer Society.
Funding AgencyGrant Number
National Cancer InstituteUNSPECIFIED
Swiss National Science Foundation (SNSF)UNSPECIFIED
Rita Allen FoundationUNSPECIFIED
American Cancer SocietyUNSPECIFIED
Issue or Number:6
Record Number:CaltechAUTHORS:20200415-141031630
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Official Citation:Laura A. Johnston, David A. Prober, Bruce A. Edgar, Robert N. Eisenman, Peter Gallant, Drosophila myc Regulates Cellular Growth during Development, Cell, Volume 98, Issue 6, 1999, Pages 779-790, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102566
Deposited By: Tony Diaz
Deposited On:15 Apr 2020 21:16
Last Modified:16 Nov 2021 18:13

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