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MicroRNAs: new regulators of immune cell development and function

Baltimore, David and Boldin, Mark P. and O'Connell, Ryan M. and Rao, Dinesh S. and Taganov, Konstantin D. (2008) MicroRNAs: new regulators of immune cell development and function. Nature Immunology, 9 (8). pp. 839-845. ISSN 1529-2908. doi:10.1038/ni.f.209.

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Decades of research went into understanding immune cell development and function without awareness that consideration of a key element, microRNA (miRNA), was lacking. The discovery of miRNAs as regulators of developmental events in model organisms suggested to many investigators that miRNA might be involved in the immune system. In the past few years, widespread examination of this possibility has produced notable results. Results have shown that miRNAs affect mammalian immune cell differentiation, the outcome of immune responses to infection and the development of diseases of immunological origin. Some miRNAs repress expression of target proteins with well established functions in hematopoiesis. Here we bring together much of this work, which has so far only scratched the surface of this very fertile field of investigation, and show how the results illuminate many historic questions about hematopoiesis and immune function.

Item Type:Article
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URLURL TypeDescription ReadCube access
Baltimore, David0000-0001-8723-8190
Boldin, Mark P.0000-0003-4593-0669
Rao, Dinesh S.0000-0002-0794-9337
Additional Information:© 2008 Nature Publishing Group. Published 21 July 2008. Issue Date August 2008. We apologize to those whose work we were unable to cite because of space limitations. We thank C. Koenig for developing the diagram presented in Figure 1. Supported by the US National Institutes of Health (D.B), the Irvington Institute Fellowship Program of the Cancer Research Institute (R.M.O.) and the American Society of Hematology (D.S.R.).
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Cancer Research InstituteUNSPECIFIED
American Society of HematologyUNSPECIFIED
Issue or Number:8
Record Number:CaltechAUTHORS:20200417-142716682
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Official Citation:Baltimore, D., Boldin, M., O'Connell, R. et al. MicroRNAs: new regulators of immune cell development and function. Nat Immunol 9, 839–845 (2008).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102618
Deposited By: George Porter
Deposited On:20 Apr 2020 14:20
Last Modified:16 Nov 2021 18:13

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