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Increased template activity of liver chromatin, a result of hydrocortisone administration

Dahmus, Michael E. and Bonner, James (1965) Increased template activity of liver chromatin, a result of hydrocortisone administration. Proceedings of the National Academy of Sciences of the United States of America, 54 (5). pp. 1370-1375. ISSN 0027-8424. https://resolver.caltech.edu/CaltechAUTHORS:DAHpnas65

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Abstract

We have found that the administration of hydrocortisone to adrenalectomized rats increases the template activity of their liver chromatin for RNA synthesis. Such administration is known to cause a two- to threefold increase in rate of nuclear RNA synthesis in the liver (1,2). This increase is followed by an increase in the activities of a series of liver enzymes (3-5). Since the induction of these enzymes by hydrocortisone is abolished by simultaneous treatment with actinomycin D, it is clear that new RNA synthesis is required to support their formation (4,5). The increased rate of liver RNA synthesis caused by administration of hydrocortisone might in principle be due to changes in the template activity of the liver genetic material such as would accompany derepression of genes previously repressed. We shall show below that the administration of hydrocortisone does result in an increased availability of the genetic material for transcription.


Item Type:Article
Additional Information:© 1965 by the National Academy of Sciences. Communicated September 24, 1965. The authors gratefully acknowledge the counsel of their colleagues, Professor Ru-chih C. Huang and Drs. Keiji Marushige, Roger Chalkley, and Ronald H. Jensen. Report of work supplied in part by U.S. Public Health Service grants GM-5143, GM-3977, and AM-3102, as well as by Public Health Service training grant GM-86.
Issue or Number:5
Record Number:CaltechAUTHORS:DAHpnas65
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:DAHpnas65
Alternative URL:http://www.pnas.org/cgi/reprint/54/5/1370
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10263
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Apr 2008
Last Modified:03 Oct 2019 00:08

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