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Guidelines and definitions for research on epithelial–mesenchymal transition

Yang, Jing and Antin, Parker and Berx, Geert and Blanpain, Cédric and Brabletz, Thomas and Bronner-Fraser, Marianne and Campbell, Kyra and Cano, Amparo and Casanova, Jordi and Christofori, Gerhard and Dedhar, Shoukat and Derynck, Rik and Ford, Heide L. and Fuxe, Jonas and García de Herreros, Antonio and Goodall, Gregory J. and Hadjantonakis, Anna-Katerina and Huang, Ruby J. Y. and Kalcheim, Chaya and Kalluri, Raghu and Kang, Yibin and Khew-Goodall, Yeesim and Levine, Herbert and Liu, Jinsong and Longmore, Gregory D. and Mani, Sendurai A. and Massagué, Joan and Mayor, Roberto and McClay, David and Mostov, Keith E. and Newgreen, Donald F. and Nieto, M. Angela and Puisieux, Alain and Runyan, Raymond and Savagner, Pierre and Stanger, Ben and Stemmler, Marc P. and Takahashi, Yoshiko and Takeichi, Masatoshi and Theveneau, Eric and Thiery, Jean Paul and Thompson, Erik W. and Weinberg, Robert A. and Williams, Elizabeth D. and Xing, Jianhua and Zhou, Binhua P. and Sheng, Guojun (2020) Guidelines and definitions for research on epithelial–mesenchymal transition. Nature Reviews. Molecular Cell Biology, 21 (6). pp. 341-352. ISSN 1471-0072. https://resolver.caltech.edu/CaltechAUTHORS:20200420-125839736

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Abstract

Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by ‘the EMT International Association’ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1038/s41580-020-0237-9DOIArticle
https://temtia.orgRelated ItemTEMTIA
ORCID:
AuthorORCID
Yang, Jing0000-0001-8410-3549
Bronner-Fraser, Marianne0000-0003-4274-1862
Fuxe, Jonas0000-0003-4576-9377
Kang, Yibin0000-0002-1626-6730
Mayor, Roberto0000-0001-9053-9613
Mostov, Keith E.0000-0002-8123-6247
Newgreen, Donald F.0000-0002-3467-6389
Nieto, M. Angela0000-0002-3538-840X
Puisieux, Alain0000-0002-9938-3798
Runyan, Raymond0000-0002-7410-916X
Stemmler, Marc P.0000-0002-7866-3686
Takeichi, Masatoshi0000-0002-9931-3378
Theveneau, Eric0000-0001-6510-5717
Thiery, Jean Paul0000-0003-0478-5020
Thompson, Erik W.0000-0002-9723-4924
Williams, Elizabeth D.0000-0002-3364-6655
Xing, Jianhua0000-0002-3700-8765
Additional Information:© 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Accepted 11 March 2020; Published 16 April 2020. We sincerely apologize to the many researchers whose work we were unable to cite due to space restrictions. Author Contributions: All authors contributed to the discussion of content and to the writing and/or revision of the article. The authors declare no competing interests.
Subject Keywords:Cancer; Developmental biology; Epithelial–mesenchymal transition
Issue or Number:6
Record Number:CaltechAUTHORS:20200420-125839736
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200420-125839736
Official Citation:Yang, J., Antin, P., Berx, G. et al. Guidelines and definitions for research on epithelial–mesenchymal transition. Nat Rev Mol Cell Biol 21, 341–352 (2020). https://doi.org/10.1038/s41580-020-0237-9
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102660
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Apr 2020 20:59
Last Modified:21 May 2020 20:43

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