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Transcranial Focused Ultrasound Generates Skull-Conducted Shear Waves: Computational Model and Implications for Neuromodulation

Salahshoor, Hossein and Shapiro, Mikhail G. and Ortiz, Michael (2020) Transcranial Focused Ultrasound Generates Skull-Conducted Shear Waves: Computational Model and Implications for Neuromodulation. Applied Physics Letters, 117 (3). Art. No. 033702. ISSN 0003-6951. PMCID PMC7386437. https://resolver.caltech.edu/CaltechAUTHORS:20200420-131214393

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Abstract

Focused ultrasound (FUS) is an established technique for non-invasive surgery and has recently attracted considerable attention as a potential method for non-invasive neuromodulation. While the pressure waves in FUS procedures have been extensively studied in this context, the accompanying shear waves are often neglected due to the relatively high shear compliance of soft tissues. However, in bony structures such as the skull, acoustic pressure can also induce significant shear waves that could propagate outside the ultrasound focus. Here, we investigate wave propagation in the human cranium by means of a finite-element model that accounts for the anatomy, elasticity, and viscoelasticity of the skull and brain. We show that, when a region on the scalp is subjected to FUS, the skull acts as a waveguide for shear waves that propagate with a speed close to 1500 m/s, reaching off-target structures such as the cochlea. In particular, when a sharp onset of FUS is introduced in a zone proximal to the intersection of the parietal and temporal cranium, the bone-propagated shear waves reach the inner ear in about 40 μs, leading to cumulative displacements of about 1 μm. We further quantify the effect of ramped and sharp application of FUS on the cumulative displacements in the inner ear. Our results help explain the off-target auditory responses observed during neuromodulation experiments and inform the development of mitigation and sham control strategies.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1063/5.0011837DOIArticle
https://doi.org/10.1101/2020.04.16.045237DOIDiscussion Paper
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7386437/PubMed CentralArticle
ORCID:
AuthorORCID
Shapiro, Mikhail G.0000-0002-0291-4215
Ortiz, Michael0000-0001-5877-4824
Additional Information:© 2020 Published under license by AIP Publishing. Submitted: 24 April 2020; Accepted: 22 June 2020; Published Online: 24 July 2020. The authors thank Dr. Richard Chadwick for helpful discussions. The authors also thank Dr. Hongsun Guo for insightful discussions and input. The authors also thank the reviewers for their valuable feedback and comments. This project was supported by U.S. National Institutes of Health Grant No. 1RF1MH117080. The authors declare no competing financial interest.
Group:GALCIT
Funders:
Funding AgencyGrant Number
NIH1RF1MH117080
Issue or Number:3
PubMed Central ID:PMC7386437
Record Number:CaltechAUTHORS:20200420-131214393
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200420-131214393
Official Citation:Transcranial focused ultrasound generates skull-conducted shear waves: Computational model and implications for neuromodulation. Hossein Salahshoor, Mikhail G. Shapiro, and Michael Ortiz. Applied Physics Letters 117:3; doi: 10.1063/5.0011837
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102662
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Apr 2020 20:48
Last Modified:03 Aug 2020 20:37

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