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Gold Nanocages for Cancer Imaging and Therapy

Au, Leslie and Chen, Jingyi and Wang, Lihong V. and Xia, Younan (2010) Gold Nanocages for Cancer Imaging and Therapy. In: Cancer Nanotechnology: Methods and Protocols. Methods in Molecular Biology. No.624. Humana Press , Totowa, NJ, pp. 83-99. ISBN 978-1-60761-608-5.

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Gold nanocages are hollow nanostructures with porous walls that can be simply prepared via the galvanic replacement reaction between silver nanocubes and chloroauric acid. Their optical resonance peaks can be precisely tuned into the near-infrared region, in which the adsorption caused by blood or soft tissue is essentially negligible. Significantly, the strong absorption of gold nanocages makes them attractive as a novel class of contrast enhancement and photothermal agents for cancer detection and treatment. The well-established chemistry for gold also allows them to target specific cells by functionalizing their surface with various moieties such as antibodies, peptides, and DNAs. In this chapter, we focus on their use as a photothermal agent for the ablation of cancer cells and as a contrast agent for the in vivo noninvasive photoacoustic imaging of blood vessels and the sentinel lymph nodes in rats.

Item Type:Book Section
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Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 Springer Science+Business Media, LLC. First Online 25 January 2010.
Subject Keywords:Localized surface plasmon resonance; hollow nanostructures; galvanic replacement reaction; silver nanocube; gold nanocage; contrast agent; photoacoustic imaging; photothermal therapy
Series Name:Methods in Molecular Biology
Issue or Number:624
Record Number:CaltechAUTHORS:20200421-081138284
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102683
Deposited By: Tony Diaz
Deposited On:21 Apr 2020 16:23
Last Modified:21 Apr 2020 16:23

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