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A shared neural substrate for action verbs and observed actions in human posterior parietal cortex

Aflalo, T. and Zhang, C. Y. and Rosario, E. R. and Pouratian, N. and Orban, G. A. and Andersen, R. A. (2020) A shared neural substrate for action verbs and observed actions in human posterior parietal cortex. Science Advances, 6 (43). Art. No. eabb3984. ISSN 2375-2548. https://resolver.caltech.edu/CaltechAUTHORS:20200421-131805901

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Abstract

High-level sensory and motor cortical areas are activated when processing the meaning of language, but it is unknown whether, and how, words share a neural substrate with corresponding sensorimotor representations. We recorded from single neurons in human posterior parietal cortex (PPC) while participants viewed action verbs and corresponding action videos from multiple views. We find that PPC neurons exhibit a common neural substrate for action verbs and observed actions. Further, videos were encoded with mixtures of invariant and idiosyncratic responses across views. Action verbs elicited selective responses from a fraction of these invariant and idiosyncratic neurons, without preference, thus associating with a statistical sampling of the diverse sensory representations related to the corresponding action concept. Controls indicated that the results are not the product of visual imagery or arbitrary learned associations. Our results suggest that language may activate the consolidated visual experience of the reader.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1126/sciadv.abb3984DOIArticle
https://advances.sciencemag.org/content/suppl/2020/10/19/6.43.eabb3984.DC1PublisherSupplementary Materials
https://doi.org/10.1101/2020.04.20.039529DOIDiscussion Paper
ORCID:
AuthorORCID
Aflalo, T.0000-0002-0101-2455
Andersen, R. A.0000-0002-7947-0472
Additional Information:© 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). Submitted 25 February 2020; Accepted 3 September 2020; Published 23 October 2020. We would like to thank N.S. and E.G.S. for participating in the studies, V. Scherbatyuk for technical assistance, and K. Pejsa for administrative and regulatory assistance. We would also like to thank M. Rugg for helpful comments on an early version of this manuscript. This work was supported by the NIH (R01EY015545), the Tianqiao and Chrissy Chen Brain-machine Interface Center at Caltech, the Conte Center for Social Decision Making at Caltech (P50MH094258), the Boswell Foundation, and ERC (Parietal action) VII FP (323606). Author contributions: Conceptualization: T.A. Methodology: T.A. and G.A.O. Investigation: T.A. and C.Y.Z. Formal analysis: T.A. Writing (original draft): T.A. Writing (review and editing): T.A., G.A.O., and R.A.A. Funding acquisition: T.A., G.A.O., and R.A.A. Resources: E.R.R. and N.P. Supervision: T.A., G.A.O., and R.A.A. The authors declare that they have no competing interests. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper may be requested from the authors.
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funders:
Funding AgencyGrant Number
NIHR01EY015545
Tianqiao and Chrissy Chen Institute for NeuroscienceUNSPECIFIED
Caltech Conte Center for the Neurobiology of Social Decision MakingUNSPECIFIED
NIHP50MH094258
James G. Boswell FoundationUNSPECIFIED
European Research Council (ERC)323606
Issue or Number:43
Record Number:CaltechAUTHORS:20200421-131805901
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200421-131805901
Official Citation:T. Aflalo, C. Y. Zhang, E. R. Rosario, N. Pouratian, G. A. Orban, R. A. Andersen, A shared neural substrate for action verbs and observed actions in human posterior parietal cortex. Sci. Adv. 6, eabb3984 (2020).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102702
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Apr 2020 20:28
Last Modified:04 Nov 2020 18:16

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