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An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

Beg, Amer A, and Baltimore, David (1996) An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death. Science, 274 (5288). pp. 782-784. ISSN 0036-8075. doi:10.1126/science.274.5288.782.

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Studies on mice deficient in nuclear factor kappa B (NF-κB) subunits have shown that this transcription factor is important for lymphocyte responses to antigens and cytokine-inducible gene expression. In particular, the RelA (p65) subunit is required for induction of tumor necrosis factor-α (TNF-α)-dependent genes. Treatment of RelA-deficient (RelA^(−/−)) mouse fibroblasts and macrophages with TNF-α resulted in a significant reduction in viability, whereas RelA^(+/+) cells were unaffected. Cytotoxicity to both cell types was mediated by TNF receptor 1. Reintroduction of RelA into RelA^(−/−) fibroblasts resulted in enhanced survival, demonstrating that the presence of RelA is required for protection from TNF-α. These results have implications for the treatment of inflammatory and proliferative diseases.

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Baltimore, David0000-0001-8723-8190
Alternate Title:An Essential Role for NF-kappa B in Preventing TNF-alpha -Induced Cell Death
Additional Information:© 1996 American Association for the Advancement of Science. 6 August 1996; accepted 2 October 1996. We thank L. Herzenberg (Stanford University) for the plasmid pON 405, A. Gifford for technical assistance, and members of our laboratory for discussions and comments. A.A.B. was supported by a Concern Il-Cancer Research Institute Fellowship. D.B. is an American Cancer Society Research Professor. Supported by a grant from the Amgen Corporation.
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Concern Il-Cancer Research InstituteUNSPECIFIED
American Cancer SocietyUNSPECIFIED
Issue or Number:5288
Record Number:CaltechAUTHORS:20200422-151000419
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Official Citation:An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death BY AMER A. BEG, DAVID BALTIMORE Science 01 Nov 1996: Vol. 274, Issue 5288, pp. 782-784 DOI: 10.1126/science.274.5288.782
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102738
Deposited By: George Porter
Deposited On:22 Apr 2020 22:40
Last Modified:16 Nov 2021 18:14

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