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NF-κB Activation: The IκB Kinase Revealed?

Stancovski, Ilana and Baltimore, David (1997) NF-κB Activation: The IκB Kinase Revealed? Cell, 91 (3). pp. 299-302. ISSN 0092-8674. https://resolver.caltech.edu/CaltechAUTHORS:20200423-120625235

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Abstract

More than a decade ago, the transcriptional activator NF-κB was described as a protein that bound to a specific DNA site in the intronic enhancer of the immunoglobulin κ light chain gene (Sen and Baltimore 1986). Following the cloning of genes encoding the p50 and p65 subunits of NF-κB, it became evident that both subunits are members of the larger NF-κB/Rel family of transcriptional regulator proteins. Since its initial description, our view of the role of NF-κB in immune and inflammatory responses has broadened significantly (for reviews, see 1, 2).


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/s0092-8674(00)80413-4DOIArticle
ORCID:
AuthorORCID
Baltimore, David0000-0001-8723-8190
Additional Information:© 1997 Cell Press. Under an Elsevier user license.
Issue or Number:3
Record Number:CaltechAUTHORS:20200423-120625235
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200423-120625235
Official Citation:Ilana Stancovski, David Baltimore, NF-κB Activation: The IκB Kinase Revealed?, Cell, Volume 91, Issue 3, 1997, Pages 299-302, ISSN 0092-8674, https://doi.org/10.1016/S0092-8674(00)80413-4.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:102749
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:23 Apr 2020 19:32
Last Modified:23 Apr 2020 19:32

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