Saksela, Kalle and Stevens, Cladd E. and Rubinstein, Pablo and Taylor, Patricia E. and Baltimore, David (1995) HIV-1 Messenger RNA in Peripheral Blood Mononuclear Cells as an Early Marker of Risk for Progression to AIDS. Annals of Internal Medicine, 123 (9). pp. 641-648. ISSN 0003-4819. doi:10.7326/0003-4819-123-9-199511010-00001. https://resolver.caltech.edu/CaltechAUTHORS:20200424-091648599
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Abstract
Objective: To establish human immunodeficiency virus type 1 (HIV-1) messenger RNA (mRNA) expression in peripheral blood mononuclear cells as a marker of risk for progression to the acquired immunodeficiency syndrome (AIDS) in a large cohort of HIV-infected persons followed for a prolonged period. Design: Retrospective testing of cryopreserved, coded specimens. Setting: Research laboratories at the New York Blood Center and the Rockefeller University. Patients: 150 homosexual men infected with HIV-1 who did not have an AIDS diagnosis at the time of testing. Measurements: Multiply spliced and unspliced HIV-1 mRNAs in total peripheral blood mononuclear cell RNA were quantitated using reverse transcriptase-initiated polymerase chain reaction (PCR) and compared with other laboratory data and clinical outcome during the subsequent 8 years. Results: Although HIV-1 mRNA expression generally correlated with immunologic status, it was associated with future disease progression independently of CD4+ cell counts or their rate of decrease at the time of sampling. The association of HIV-1 mRNA with disease progression in persons with CD4+ cell counts higher than the median (> 624 cells/mm³) was particularly noteworthy; further variation in the CD4+ cell counts within this group was not prognostically significant. Conclusions: The expression of HIV-1 mRNA in peripheral blood mononuclear cells is a strong independent marker for future HIV disease progression, even in persons with normal T-cell subsets.
Item Type: | Article | ||||||
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Additional Information: | © 1995 American College of Physicians. | ||||||
Issue or Number: | 9 | ||||||
DOI: | 10.7326/0003-4819-123-9-199511010-00001 | ||||||
Record Number: | CaltechAUTHORS:20200424-091648599 | ||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20200424-091648599 | ||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
ID Code: | 102768 | ||||||
Collection: | CaltechAUTHORS | ||||||
Deposited By: | Tony Diaz | ||||||
Deposited On: | 24 Apr 2020 17:27 | ||||||
Last Modified: | 16 Nov 2021 18:15 |
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