Oettinger, Marjorie A. and Stanger, Ben and Schatz, David G. and Glaser, Tom and Call, Kathy and Housman, David and Baltimore, David (1992) The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice. Immunogenetics, 35 (2). pp. 97-101. ISSN 0093-7711. doi:10.1007/bf00189518. https://resolver.caltech.edu/CaltechAUTHORS:20200427-082038556
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Abstract
The recombination activating genes RAG-1 and RAG-2 are adjacent genes that act synergistically to activate variable-diversity-joining (V(D)J) recombination. Southern analysis of hybrid cell lines derived from patients with the Wilms tumor-aniridia-genitourinary defects-mental retardation (WAGR) syndrome and from mutagenized cell hybrids selected for deletions in chromosome 11 has allowed us to map the chromosomal location of the human RAG locus. The RAG locus defines a new interval of human chromosome 11p, but is not associated with any genetically mapped human disease. Guided by the chromosomal localization of the human recombination activating genes, we have also mapped the location of the mouse Rag locus.
Item Type: | Article | ||||||
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Additional Information: | © 1992 Springer-Verlag. Received 25 March 1991; Revised 11 June 1991. | ||||||
Subject Keywords: | Human Disease; Activate Gene; Human Chromosome; Chromosomal Localization; Cell Hybrid | ||||||
Issue or Number: | 2 | ||||||
DOI: | 10.1007/bf00189518 | ||||||
Record Number: | CaltechAUTHORS:20200427-082038556 | ||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20200427-082038556 | ||||||
Official Citation: | Oettinger, M.A., Stanger, B., Schatz, D.G. et al. The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice. Immunogenetics 35, 97–101 (1992). https://doi.org/10.1007/BF00189518 | ||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
ID Code: | 102783 | ||||||
Collection: | CaltechAUTHORS | ||||||
Deposited By: | Tony Diaz | ||||||
Deposited On: | 27 Apr 2020 17:43 | ||||||
Last Modified: | 16 Nov 2021 18:15 |
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